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MedKoo Cat#: 532928 | Name: DCPIB
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DCPIB is a novel Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulating K2P Channels.

Chemical Structure

DCPIB
DCPIB
CAS#82749-70-0

Theoretical Analysis

MedKoo Cat#: 532928

Name: DCPIB

CAS#: 82749-70-0

Chemical Formula: C22H28Cl2O4

Exact Mass: 426.1365

Molecular Weight: 427.36

Elemental Analysis: C, 61.83; H, 6.60; Cl, 16.59; O, 14.97

Price and Availability

Size Price Availability Quantity
100mg USD 850.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
No Data
Synonym
DCPIB; SN-401; SN401; SN 401;
IUPAC/Chemical Name
4-((2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid
InChi Key
KHKGTPJPBOQECW-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28Cl2O4/c1-2-3-10-22(15-7-4-5-8-15)13-14-12-16(28-11-6-9-17(25)26)19(23)20(24)18(14)21(22)27/h12,15H,2-11,13H2,1H3,(H,25,26)
SMILES Code
O=C(O)CCCOC1=CC2=C(C(C(C3CCCC3)(CCCC)C2)=O)C(Cl)=C1Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 427.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lv J, Liang Y, Zhang S, Lan Q, Xu Z, Wu X, Kang L, Ren J, Cao Y, Wu T, Lin KL, Yung KKL, Cao X, Pang J, Zhou P. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019 Jun 19;10(6):2786-2793. doi: 10.1021/acschemneuro.9b00010. Epub 2019 Apr 17. PMID: 30935201. 2: Zhi Y, Liu J, Kuang P, Zhang X, Xu Z, Chen Y, Lin X, Wu X, Zhou P, Chen J. Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses. Biochem Pharmacol. 2022 May;199:114988. doi: 10.1016/j.bcp.2022.114988. Epub 2022 Mar 10. PMID: 35278418. 3: Cao G, Guo J, Yang K, Xu R, Jia X, Wang X. DCPIB Attenuates Ischemia- Reperfusion Injury by Regulating Microglial M1/M2 Polarization and Oxidative Stress. Neuroscience. 2024 Jul 23;551:119-131. doi: 10.1016/j.neuroscience.2024.05.008. Epub 2024 May 9. PMID: 38734301. 4: Zuccolini P, Ferrera L, Remigante A, Picco C, Barbieri R, Bertelli S, Moran O, Gavazzo P, Pusch M. The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca2+ in melanoma and pancreatic duct adenocarcinoma cell lines. Br J Pharmacol. 2022 Jul;179(13):3452-3469. doi: 10.1111/bph.15810. Epub 2022 Feb 28. PMID: 35102550. 5: Han Q, Liu S, Li Z, Hu F, Zhang Q, Zhou M, Chen J, Lei T, Zhang H. DCPIB, a potent volume-regulated anion channel antagonist, attenuates microglia-mediated inflammatory response and neuronal injury following focal cerebral ischemia. Brain Res. 2014 Jan 13;1542:176-85. doi: 10.1016/j.brainres.2013.10.026. Epub 2013 Nov 1. PMID: 24189520. 6: Bowens NH, Dohare P, Kuo YH, Mongin AA. DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cells. Mol Pharmacol. 2013 Jan;83(1):22-32. doi: 10.1124/mol.112.080457. Epub 2012 Sep 25. PMID: 23012257; PMCID: PMC3533478. 7: Zhang Y, Zhang H, Feustel PJ, Kimelberg HK. DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra. Exp Neurol. 2008 Apr;210(2):514-20. doi: 10.1016/j.expneurol.2007.11.027. Epub 2007 Dec 7. PMID: 18206872; PMCID: PMC2362851. 8: He D, Luo X, Wei W, Xie M, Wang W, Yu Z. DCPIB, a specific inhibitor of volume-regulated anion channels (VRACs), inhibits astrocyte proliferation and cell cycle progression via G1/S arrest. J Mol Neurosci. 2012 Feb;46(2):249-57. doi: 10.1007/s12031-011-9524-4. Epub 2011 May 11. PMID: 21559876. 9: Kern DM, Oh S, Hite RK, Brohawn SG. Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs. Elife. 2019 Feb 18;8:e42636. doi: 10.7554/eLife.42636. PMID: 30775971; PMCID: PMC6395065. 10: Decher N, Lang HJ, Nilius B, Brüggemann A, Busch AE, Steinmeyer K. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001 Dec;134(7):1467-79. doi: 10.1038/sj.bjp.0704413. PMID: 11724753; PMCID: PMC1573095.