Aditoprim | CAS# 56066-63-8 | Biochemical

MedKoo Cat#: 573942 | Name: Aditoprim

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aditoprim is an antibacterial dihydrofolate reductase inhibitor.

Chemical Structure

Aditoprim

CAS#56066-63-8

Theoretical Analysis

MedKoo Cat#: 573942

Name: Aditoprim

CAS#: 56066-63-8

Chemical Formula: C15H21N5O2

Exact Mass: 303.1695

Molecular Weight: 303.37

Elemental Analysis: C, 59.39; H, 6.98; N, 23.09; O, 10.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Aditoprim

IUPAC/Chemical Name

2,4-Diamino-5-(4-(dimethylamino)-3,5-dimethoxybenzyl)pyrimidine

InChi Key

QBQMXWZTRRWPGK-UHFFFAOYSA-N

InChi Code

1S/C15H21N5O2/c1-20(2)13-11(21-3)6-9(7-12(13)22-4)5-10-8-18-15(17)19-14(10)16/h6-8H,5H2,1-4H3,(H4,16,17,18,19)

SMILES Code

CN(C)c1c(cc(cc1OC)Cc2cnc(nc2N)N)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 303.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cheng G, Xu Y, Zhu X, Xie S, Wang L, Huang L, Hao H, Liu Z, Pan Y, Chen D, Wang Y, Yuan Z. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017 Feb 1;7:41370. doi: 10.1038/srep41370. PubMed PMID: 28145487; PubMed Central PMCID: PMC5286432. 2: Wang L, Huang L, Pan Y, Wu Q, Xie S, Yuan Z. Simultaneous determination of aditoprim and its three major metabolites in pigs, broilers and carp tissues, and its application in tissue distribution and depletion studies. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Aug;33(8):1299-311. doi: 10.1080/19440049.2016.1200751. Epub 2016 Jul 27. PubMed PMID: 27310088. 3: Wang X, Tan Z, Pan Y, Ihsan A, Liu Q, Huang L, Cheng G, Chen D, Tao Y, Liu Z, Yuan Z. Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies. J Appl Toxicol. 2015 Nov;35(11):1415-26. doi: 10.1002/jat.3107. Epub 2015 Feb 7. PubMed PMID: 25663419.