Synonym
Florantyrone; Bilyn; Florantirona; Cistoplex; Fluochol; Idrobil; Idroepar; Zanchol; SC 1674; SC-1674; SC1674;
IUPAC/Chemical Name
4-(fluoranthen-8-yl)-4-oxobutanoic acid
InChi Key
QOBAOSCOLAGPKI-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H14O3/c21-18(9-10-19(22)23)13-7-8-14-15-5-1-3-12-4-2-6-16(20(12)15)17(14)11-13/h1-8,11H,9-10H2,(H,22,23)
SMILES Code
O=C(O)CCC(C1=CC(C2=C3C4=CC=CC3=CC=C2)=C4C=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
302.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: PARKER JW, GRODSKY GM, CARBONE JV. A study of the metabolites of florantyrone. Gastroenterology. 1961 Dec;41:563-7. PubMed PMID: 14483923.
2: MEEROFF M. [Hydrocholeretic action of florantyrone]. Prensa Med Argent. 1958 Mar 21;45(12):1272-6. Spanish. PubMed PMID: 13591251.
3: ACHESON ED, McHARDY G, DESSAUER HC, FORD C, DUNN D. Effect of florantyrone on rate of secretion of hepatic bile and on its chemical and physical properties. Gastroenterology. 1959 Dec;37:735-40. PubMed PMID: 13791630.
4: Rodríguez Garay E, Noir B, Colombato L, Parodi H, Royer M. [Formation of biliverdin by the action of florantyrone]. Medicina (B Aires). 1965 May-Jun;25(3):175-9. Spanish. PubMed PMID: 5846616.
5: Kirkpatrick JR, Eastwood MA, Mitchell WD. Proceedings: The effect of florantyrone (Zanchol) on the composition of T-tube bile. Gut. 1974 Oct;15(10):830. PubMed PMID: 4434947.
6: Gershbein LL, Pedroso AF. Action of drugs and chemical agents on rat liver regeneration. Drug Chem Toxicol. 1985;8(3):125-43. PubMed PMID: 2932325.
7: Nottle PD, Hughes E. Gallstones: operate, dissolve or leave alone? Drugs. 1981 Apr;21(4):302-8. PubMed PMID: 7227221.
8: Turley SD, Dietschy JM. Effects of clofibrate, cholestyramine, zanchol, probucol, and AOMA feeding on hepatic and intestinal cholesterol metabolism and on biliary lipid secretion in the rat. J Cardiovasc Pharmacol. 1980;2(3):281-97. PubMed PMID: 6156326.
9: WISSMER B, CHAFIZADEH M. [Clinical value of zanchol, new choleretic]. Praxis. 1959 Dec 24;48:1197-9. French. PubMed PMID: 13845423.
10: SCHWARTZ IR, LEHMAN E, SEIBEL JM. Clinical impressions of a new hydrocholeretic agent, zanchol. Am J Gastroenterol. 1959 Jan;31(1):28-33. PubMed PMID: 13606110.
11: Cohen H, Bonorris GG, Marks JW, Schoenfield LJ. Effect of Zanchol and chenic acid on bile acid pool size and gallstones in hamsters. Am J Med Sci. 1982 Jan-Feb;283(1):23-31. PubMed PMID: 7055157.
