(S)-Pomalidomide | CAS# 202271-89-4 | Angiogenesis Inhibitor

MedKoo Cat#: 558762 | Name: (S)-Pomalidomide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(S)-Pomalidomide is an inhibitor of angiogenesis and growth of B-cell neoplasias, which induces complete regressions of Burkitt's lymphoma cell tumors.

Chemical Structure

(S)-Pomalidomide

CAS#202271-89-4

Theoretical Analysis

MedKoo Cat#: 558762

Name: (S)-Pomalidomide

CAS#: 202271-89-4

Chemical Formula: C13H11N3O4

Exact Mass: 273.0750

Molecular Weight: 273.25

Elemental Analysis: C, 57.14; H, 4.06; N, 15.38; O, 23.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

(S)-Pomalidomide; (S) Pomalidomide; S-Pomalidomide; S Pomalidomide; S-3APG; S 3APG; S3APG; (S)-CC-4047; (S) CC-4047; (S)-CC4047

IUPAC/Chemical Name

4-Amino-2-[(3S)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione

InChi Key

UVSMNLNDYGZFPF-QMMMGPOBSA-N

InChi Code

InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)/t8-/m0/s1

SMILES Code

O=C1N([C@@H](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 273.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lentzsch S, Rogers MS, LeBlanc R, Birsner AE, Shah JH, Treston AM, Anderson KC, D'Amato RJ. S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice. Cancer Res. 2002 Apr 15;62(8):2300-5. PubMed PMID: 11956087. 2: Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16. PubMed PMID: 25043012; PubMed Central PMCID: PMC4423819.