NED3238 HCl | 2389062-10-4

MedKoo Cat#: 471030 | Name: NED3238 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NED3238 is new highly potent inhibitor of arginase I and II with IC50 values of 1.3 and 8.1 nM, respectively.

Chemical Structure

NED3238 HCl

CAS#2389062-10-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 471030

Name: NED3238 HCl

CAS#: 2389062-10-4 (HCl)

Chemical Formula: C17H30BCl2N3O4

Exact Mass: 0.0000

Molecular Weight: 422.15

Elemental Analysis: C, 48.37; H, 7.16; B, 2.56; Cl, 16.79; N, 9.95; O, 15.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

2389062-09-1 (free base) NED-3238 mesylate 2389062-10-4 (HCl)

Synonym

NED3238 HCl; NED3238 hydrochloride, NED3238, NED 3238, NED-3238;

IUPAC/Chemical Name

(3R,4S)-3-amino-1-((S)-2-amino-3-phenylpropyl)-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid dihydrochloride

InChi Key

YLRFCKXLPZIAMP-DQZPFBHVSA-N

InChi Code

InChI=1S/C17H28BN3O4.2ClH/c19-15(9-13-5-2-1-3-6-13)11-21-10-14(7-4-8-18(24)25)17(20,12-21)16(22)23;;/h1-3,5-6,14-15,24-25H,4,7-12,19-20H2,(H,22,23);2*1H/t14-,15-,17-;;/m0../s1

SMILES Code

O=C([C@]1(N)CN(C[C@@H](N)CC2=CC=CC=C2)C[C@@H]1CCCB(O)O)O.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 422.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Van Zandt MC, et al. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II. J Med Chem. 2019 Aug 23.