MedKoo Cat#: 555607 | Name: BAM8-22
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAM8-22 is a Endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM); first isolated from bovine adrenal medulla.

Chemical Structure

BAM8-22
BAM8-22
CAS#412961-36-5

Theoretical Analysis

MedKoo Cat#: 555607

Name: BAM8-22

CAS#: 412961-36-5

Chemical Formula: C91H127N25O23S

Exact Mass: 1969.9257

Molecular Weight: 1971.23

Elemental Analysis: C, 55.45; H, 6.49; N, 17.76; O, 18.67; S, 1.63

Price and Availability

Size Price Availability Quantity
1mg USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
BAM8-22; BAM 8-22; BAM-8-22; BAM822; BAM 822; BAM-822; BAM(8-22);
IUPAC/Chemical Name
H-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH
InChi Key
GOEYECACIBFJGZ-NPAGUKBMSA-N
InChi Code
InChI=1S/C91H127N25O23S/c1-48(2)76(94)88(138)103-46-72(120)105-64(19-11-36-100-91(97)98)89(139)116-37-12-20-70(116)87(137)110-62(30-32-73(121)122)81(131)113-68(42-52-45-102-58-16-7-5-14-56(52)58)85(135)114-67(41-51-44-101-57-15-6-4-13-55(51)57)84(134)109-63(33-38-140-3)82(132)115-69(43-74(123)124)86(136)112-66(40-50-23-27-54(118)28-24-50)83(133)108-61(29-31-71(93)119)80(130)106-59(17-8-9-34-92)78(128)107-60(18-10-35-99-90(95)96)79(129)111-65(77(127)104-47-75(125)126)39-49-21-25-53(117)26-22-49/h4-7,13-16,21-28,44-45,48,59-70,76,101-102,117-118H,8-12,17-20,29-43,46-47,92,94H2,1-3H3,(H2,93,119)(H,103,138)(H,104,127)(H,105,120)(H,106,130)(H,107,128)(H,108,133)(H,109,134)(H,110,137)(H,111,129)(H,112,136)(H,113,131)(H,114,135)(H,115,132)(H,121,122)(H,123,124)(H,125,126)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,76-/m0/s1
SMILES Code
[H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,971.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Honda M, Tsounapi P, Teraoka S, Kimura Y, Hikita K, Takenaka A. Effects of intravesical administration of sensory neuron-specific receptor agonist on voiding function in rats with cyclophosphamide-induced cystitis. Cent European J Urol. 2019;72(2):142-148. doi: 10.5173/ceju.2019.1949. Epub 2019 May 6. PubMed PMID: 31482020; PubMed Central PMCID: PMC6715086. 2: Hu Z, Zhao T, Chen T, Wang D. Chronic activation of Mas-related gene receptors (Mrg) reduces the potency of morphine-induced analgesia via PKC pathway in naive rats. Brain Res. 2019 Aug 5;1722:146363. doi: 10.1016/j.brainres.2019.146363. [Epub ahead of print] PubMed PMID: 31394092. 3: Sanjel B, Maeng HJ, Shim WS. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci Rep. 2019 Jul 26;9(1):10888. doi: 10.1038/s41598-019-47267-5. PubMed PMID: 31350433; PubMed Central PMCID: PMC6659683. 4: Tsagareli MG, Nozadze I, Tsiklauri N, Gurtskaia G. TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice. Med Sci (Basel). 2019 Apr 18;7(4). pii: E62. doi: 10.3390/medsci7040062. PubMed PMID: 31003539; PubMed Central PMCID: PMC6524052. 5: Zhang Y, Wang M, Lu Q, Li Q, Lin M, Huang J, Hong Y. Inhibitory Effects of Mas-Related Gene C Receptor on Chronic Morphine-Induced Spinal Glial Activation in Rats. J Pharmacol Exp Ther. 2019 Feb;368(2):237-245. doi: 10.1124/jpet.118.252494. Epub 2018 Nov 28. PubMed PMID: 30487293. 6: Nozadze I, Tsiklauri N, Gurtskaia G, Tsagareli M. THE ROLE OF TRANSIENT RECEPTOR POTENTIAL (TRPA1) CHANNEL IN PRURITUS. Georgian Med News. 2018 Jul-Aug;(280-281):134-137. PubMed PMID: 30204112. 7: Liu YJ, Lin XX, Fang JQ, Fang F. Involvement of MrgprC in Electroacupuncture Analgesia for Attenuating CFA-Induced Thermal Hyperalgesia by Suppressing the TRPV1 Pathway. Evid Based Complement Alternat Med. 2018 Feb 12;2018:9102107. doi: 10.1155/2018/9102107. eCollection 2018. PubMed PMID: 29619074; PubMed Central PMCID: PMC5829339. 8: Zhang Y, Wang K, Lin M, Li Q, Hong Y. Inhibition of morphine tolerance by MrgC receptor via modulation of interleukin-1β and matrix metalloproteinase 9 in dorsal root ganglia in rats. Eur J Pharmacol. 2017 Nov 15;815:10-17. doi: 10.1016/j.ejphar.2017.10.011. Epub 2017 Oct 6. PubMed PMID: 28993160. 9: Jiang YM, Huang C, Peng Z, Han SL, Li WG, Zhu MX, Xu TL. Acidosis counteracts itch tachyphylaxis to consecutive pruritogen exposure dependent on acid-sensing ion channel 3. Mol Pain. 2017 Jan-Dec;13:1744806917721114. doi: 10.1177/1744806917721114. PubMed PMID: 28745101; PubMed Central PMCID: PMC5533257. 10: Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. doi: 10.1073/pnas.1615255114. Epub 2017 Feb 21. PubMed PMID: 28223516; PubMed Central PMCID: PMC5347560. 11: Akiyama T, Nagamine M, Davoodi A, Ivanov M, Carstens MI, Carstens E. Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse. J Neurophysiol. 2017 Jan 1;117(1):251-259. doi: 10.1152/jn.00703.2016. Epub 2016 Oct 26. PubMed PMID: 27784810; PubMed Central PMCID: PMC5220113. 12: Chang AY, Mann TS, McFawn PK, Han L, Dong X, Henry PJ. Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways. Respir Res. 2016 May 23;17(1):62. doi: 10.1186/s12931-016-0378-8. PubMed PMID: 27215903; PubMed Central PMCID: PMC4877944. 13: Sun Y, Zhang J, Lei Y, Lu C, Hou B, Ma Z, Gu X. Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. Am J Transl Res. 2016 Feb 15;8(2):1144-54. eCollection 2016. PubMed PMID: 27158400; PubMed Central PMCID: PMC4846957. 14: Sun Y, Jiang M, Hou B, Lu C, Lei Y, Ma Z, Gu X. Mas-Related Gene (Mrg) C Activation Attenuates Bone Cancer Pain via Modulating Gi and NR2B. PLoS One. 2016 May 6;11(5):e0154851. doi: 10.1371/journal.pone.0154851. eCollection 2016. PubMed PMID: 27152740; PubMed Central PMCID: PMC4859570. 15: Wang D, Xue Y, Yan Y, Lin M, Yang J, Huang J, Hong Y. Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury. Neurobiol Dis. 2016 Jul;91:274-83. doi: 10.1016/j.nbd.2016.03.020. Epub 2016 Mar 24. PubMed PMID: 27018398. 16: Wang D, Xue Y, Chen Y, Ruan L, Hong Y. Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats. Neurosci Lett. 2016 Apr 8;618:115-121. doi: 10.1016/j.neulet.2016.03.004. Epub 2016 Mar 4. PubMed PMID: 26952974. 17: Sun YE, Lu CE, Lei Y, Liu Y, Ma Z, Gu X. Mas-related G-protein-coupled receptor c agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. Int J Clin Exp Med. 2015 Nov 15;8(11):20178-87. eCollection 2015. PubMed PMID: 26884930; PubMed Central PMCID: PMC4723775. 18: Kiguchi N, Sukhtankar DD, Ding H, Tanaka K, Kishioka S, Peters CM, Ko MC. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. J Pharmacol Exp Ther. 2016 Mar;356(3):596-603. doi: 10.1124/jpet.115.229997. Epub 2015 Dec 15. PubMed PMID: 26669425; PubMed Central PMCID: PMC4767390. 19: Heller D, Doyle JR, Raman VS, Beinborn M, Kumar K, Kopin AS. Novel Probes Establish Mas-Related G Protein-Coupled Receptor X1 Variants as Receptors with Loss or Gain of Function. J Pharmacol Exp Ther. 2016 Feb;356(2):276-83. doi: 10.1124/jpet.115.227058. Epub 2015 Nov 18. PubMed PMID: 26582731. 20: Jiang JP, Fu Y, Hu FJ, Hong YG. [Activation of spinal MrgC receptors inhibits hyperalgesia in rats]. Sheng Li Xue Bao. 2015 Aug 25;67(4):413-22. Chinese. PubMed PMID: 26300254.