R 8231 | CAS#50648-52-7 | inhibitor

MedKoo Cat#: 585093 | Name: R 8231

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R 8231 inhibits ATP-ase.

Chemical Structure

R 8231

CAS#50648-52-7

Theoretical Analysis

MedKoo Cat#: 585093

Name: R 8231

CAS#: 50648-52-7

Chemical Formula: C13H11BrN2O4S

Exact Mass: 369.9623

Molecular Weight: 371.21

Elemental Analysis: C, 42.06; H, 2.99; Br, 21.53; N, 7.55; O, 17.24; S, 8.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

R 8231; R8231; R-8231

IUPAC/Chemical Name

Imidazo(2,1-b)thiazole, 6-(3-bromophenyl)-5,6-dihydro-, (+-)-, ethanedioate (1:1)

InChi Key

RLCKOBLWSSOAOS-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H9BrN2S.C2H2O4/c12-9-3-1-2-8(6-9)10-7-14-4-5-15-11(14)13-10;3-1(4)2(5)6/h1-6,10H,7H2;(H,3,4)(H,5,6)

SMILES Code

BrC1=CC(C2N=C3SC=CN3C2)=CC=C1.O=C(O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 371.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Simmons DJ, Arsenis C, Whitson SW, Kahn SE, Boskey AL, Gollub N. Mineralization of rat epiphyseal cartilage: a circadian rhythm. Miner Electrolyte Metab. 1983 Jan-Feb;9(1):28-37. PubMed PMID: 6221186. 2: Engström C, Granström G. Alkaline phosphatases in endochondral ossification of rats low in calcium and vitamin D deficient. Acta Orthop Scand. 1982 Jun;53(3):317-23. PubMed PMID: 7090756. 3: Granström G, Jontell M, Linde A. Separation of odontoblast Ca2+-ATPase and alkaline phosphatase. Calcif Tissue Int. 1979 Jul 3;27(3):211-7. PubMed PMID: 158425. 4: Granström G, Linde A, Nygren H. Ultrastructural localization of alkaline phosphatases in rat incisor odontoblasts. J Histochem Cytochem. 1978 May;26(5):359-68. PubMed PMID: 26717. 5: Mörnstad H. Calcium-stimulated ATPase activity in homogenates of the secretory enamel organ in the rat. Scand J Dent Res. 1978 Jan;86(1):1-11. PubMed PMID: 24889. 6: Granström G, Linde A. A comparison of ATP-degrading enzyme activities in rat incisor odontoblasts. J Histochem Cytochem. 1976 Sep;24(9):1026-32. PubMed PMID: 9454. 7: Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6. PubMed PMID: 6169. 8: Larsson A. Histochemical localization of alkaline pyrophosphate- phosphohydrolase in tooth-forming cells of rat. Scand J Dent Res. 1976 Mar;84(2):63-75. PubMed PMID: 176719. 9: Linde A, Magnusson BC. Inhibition studies of alkaline phosphatase in hard tissue-forming cells. J Histochem Cytochem. 1975 May;23(5):342-7. PubMed PMID: 165233. 10: Fredén H, Linde A, Magnusson BC. Inorganic pyrophosphatase in isolated enamel organ and odontoblasts from the rat incisor. Acta Odontol Scand. 1975;33(3):143-8. PubMed PMID: 9771.