MedKoo Cat#: 573864 | Name: Amidephrine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amidephrine is an adrenergic agent. Amidephrine showed a selective activity on alpha 1-adrenoceptors, and failed to exert any effect on alpha 2-adrenoceptors. The alpha 1-adrenoceptor antagonists prazosin (pA2 8.19 and 8.48) and E-643 (pA2 8.36 and 8.25) inhibited the agonist activity of (-)-amidephrine

Chemical Structure

Amidephrine
Amidephrine
CAS#37571-84-9 (free base)

Theoretical Analysis

MedKoo Cat#: 573864

Name: Amidephrine

CAS#: 37571-84-9 (free base)

Chemical Formula:

Exact Mass: 0.0000

Molecular Weight: 0.00

Elemental Analysis:

Price and Availability

Size Price Availability Quantity
5mg USD 950.00 2 Weeks
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Synonym
Amidefrine, Amidephrine
IUPAC/Chemical Name
N-(3-(1-hydroxy-2-(methylamino)ethyl)phenyl)methanesulfonamide
InChi Key
ZHOWHMXTJFZXRB-UHFFFAOYSA-N
InChi Code
1S/C10H16N2O3S/c1-11-7-10(13)8-4-3-5-9(6-8)12-16(2,14)15/h3-6,10-13H,7H2,1-2H3
SMILES Code
CNCC(c1cccc(c1)NS(=O)(=O)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Br J Pharmacol. 1989 Jun;97(2):419-32. doi: 10.1111/j.1476-5381.1989.tb11969.x. PMID: 2569342; PMCID: PMC1854522. 6: DUNGAN KW, STANTON HC, LISH PM. AMIDEPHRINE--I: PHARMACOLOGIC CHARACTERIZATION OF A SYMPATHOMIMETIC ALKYLSULFONAMIDOPHENETHANOLAMINE. Int J Neuropharmacol. 1965 Jul;4:219-34. doi: 10.1016/0028-3908(65)90038-9. PMID: 14343876. 7: Mathy MJ, Doods HN, Thoolen MJ, Wilffert B, de Jonge A, Timmermans PB, Van Zwieten PA. Selective stimulation of vascular postjunctional alpha- adrenoreceptors by (-)-amidephrine in rats and cats. J Auton Pharmacol. 1983 Dec;3(4):249-55. doi: 10.1111/j.1474-8673.1983.tb00542.x. PMID: 6141169. 8: Buchthal AB, Jenkinson DH. Effects of isomers of the alpha-agonist amidephrine on arterial and tracheal muscle in vitro. Eur J Pharmacol. 1970 May;10(2):293-6. doi: 10.1016/0014-2999(70)90286-4. PMID: 4392818. 9: Blue DR, Daniels DV, Gever JR, Jett MF, O'Yang C, Tang HM, Williams TJ, Ford AP. Pharmacological characteristics of Ro 115-1240, a selective alpha1A/1L-adrenoceptor partial agonist: a potential therapy for stress urinary incontinence. BJU Int. 2004 Jan;93(1):162-70. doi: 10.1111/j.1464-410x.2004.04577.x. PMID: 14678390. 10: Jenkinson DH, Haylett DG, Cook NS. Calcium-activated potassium channels in liver cells. Cell Calcium. 1983 Dec;4(5-6):429-37. doi: 10.1016/0143-4160(83)90019-2. PMID: 6323005. 11: Docherty JR, Warnock P. An investigation of alpha-adrenoceptor responsiveness in the vas deferens of spontaneously hypertensive rats. Br J Pharmacol. 1985 Oct;86(2):327-33. doi: 10.1111/j.1476-5381.1985.tb08900.x. PMID: 2413944; PMCID: PMC1916703. 12: García-Barrado MJ, Reverte M, Palomero J, Moratinos J. Comparative effects of calcium channel blockers and indomethacin on insulin secretion and blood pressure increase derived from alpha 1-adrenoceptor stimulation in the rabbit. J Auton Pharmacol. 1997 Oct;17(5):293-302. doi: 10.1046/j.1365-2680.1997.00463.x. PMID: 9427108. 13: Gater PR, Haylett DG, Jenkinson DH. Neuromuscular blocking agents inhibit receptor-mediated increases in the potassium permeability of intestinal smooth muscle. Br J Pharmacol. 1985 Dec;86(4):861-8. doi: 10.1111/j.1476-5381.1985.tb11108.x. PMID: 2866804; PMCID: PMC1916639. 14: Chiu AT, McCall DE, Thoolen MJ, Timmermans PB. Ca++ utilization in the constriction of rat aorta to full and partial alpha-1 adrenoceptor agonists. J Pharmacol Exp Ther. 1986 Jul;238(1):224-31. PMID: 2873236. 15: Michel AD, Loury DN, Whiting RL. Identification of a single alpha 1-adrenoceptor corresponding to the alpha 1A-subtype in rat submaxillary gland. Br J Pharmacol. 1989 Nov;98(3):883-9. doi: 10.1111/j.1476-5381.1989.tb14617.x. PMID: 2556204; PMCID: PMC1854785. 16: Wilson VG, Wilson KA, Downing OA. A comparison of the ability of various alpha-adrenoreceptor agonists to induce EGTA-resistant contractions of rat aorta. J Auton Pharmacol. 1987 Mar;7(1):61-9. doi: 10.1111/j.1474-8673.1987.tb00134.x. PMID: 2886504. 17: García-Barrado MJ, Sancho C, Palomero J, Moratinos J. Role of alpha2-adrenoceptors on the hyperglycaemic and insulin secretory effects derived from alpha1- and beta-adrenoceptor stimulation in the rabbit. J Auton Pharmacol. 1998 Oct;18(5):287-95. doi: 10.1046/j.1365-2680.1998.18596.x. PMID: 9831229. 18: Moratinos J, Carpene C, de Pablos I, Reverte M. Role of alpha 1- and alpha 2-adrenoceptors in catecholamine-induced hyperglycaemia, lipolysis and insulin secretion in conscious fasted rabbits. Br J Pharmacol. 1988 Jun;94(2):299-310. doi: 10.1111/j.1476-5381.1988.tb11531.x. PMID: 2840157; PMCID: PMC1853986. 19: Williamson KL, Broadley KJ. Characterization of the alpha-adrenoceptors mediating positive inotropy of rat left atria by use of selective agonists and antagonists. Arch Int Pharmacodyn Ther. 1987 Feb;285(2):181-98. PMID: 2883945. 20: Aboud R, Shafii M, Docherty JR. Investigation of the subtypes of alpha 1-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen. Br J Pharmacol. 1993 May;109(1):80-7. doi: 10.1111/j.1476-5381.1993.tb13534.x. PMID: 8098642; PMCID: PMC2175602.