MedKoo Cat#: 555598 | Name: KL-1333

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts.

Chemical Structure

KL-1333
KL-1333
CAS#1800405-30-4

Theoretical Analysis

MedKoo Cat#: 555598

Name: KL-1333

CAS#: 1800405-30-4

Chemical Formula: C14H12N2O2

Exact Mass: 240.0899

Molecular Weight: 240.26

Elemental Analysis: C, 69.99; H, 5.03; N, 11.66; O, 13.32

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
KL-1333; KL 1333; KL1333; napazimonum; napazimone
IUPAC/Chemical Name
2-(1-Methylethyl)-3H-naphth(1,2-d)imidazole-4,5-dione
InChi Key
AJFWITSBVLLDCC-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12N2O2/c1-7(2)14-15-10-8-5-3-4-6-9(8)12(17)13(18)11(10)16-14/h3-7H,1-2H3,(H,15,16)
SMILES Code
O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), one of the most common maternally inherited mitochondrial diseases, is caused by mitochondrial DNA mutations that lead to mitochondrial dysfunction. Several treatment options exist, including supplementation with CoQ10, vitamins, and nutrients, but no treatment with proven efficacy is currently available.

Preparing Stock Solutions

The following data is based on the product molecular weight 240.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL