MedKoo Cat#: 532402 | Name: Isophthalamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isophthalamide is a bioactive chemical.

Chemical Structure

Isophthalamide
Isophthalamide
CAS#1740-57-4

Theoretical Analysis

MedKoo Cat#: 532402

Name: Isophthalamide

CAS#: 1740-57-4

Chemical Formula: C8H8N2O2

Exact Mass: 164.0586

Molecular Weight: 164.16

Elemental Analysis: C, 58.53; H, 4.91; N, 17.06; O, 19.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Isophthalamide
IUPAC/Chemical Name
Isophthalamide
InChi Key
QZUPTXGVPYNUIT-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H8N2O2/c9-7(11)5-2-1-3-6(4-5)8(10)12/h1-4H,(H2,9,11)(H2,10,12)
SMILES Code
O=C(N)C1=CC=CC(C(N)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 164.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide Asmaa F. Kassem, Gaber O. Moustafa, Eman S. Nossier, Hemat S. Khalaf, Marwa M. Mounier, Suliman A. Al-Yousef, Sabry Y. Mahmoud J Enzyme Inhib Med Chem. 2019; 34(1): 1247–1258. Published online 2019 Jul 9. doi: 10.1080/14756366.2019.1613390 PMCID: PMC6691786 2: Amelioration of Acute Mercury Toxicity by a Novel, Non-Toxic Lipid Soluble Chelator N,N′bis-(2-mercaptoethyl)isophthalamide: Effect on Animal Survival, Health, Mercury Excretion and Organ Accumulation David Clarke, Roger Buchanan, Niladri Gupta, Boyd Haley Toxicol Environ Chem. Author manuscript; available in PMC 2012 May 7.Published in final edited form as: Toxicol Environ Chem. 2012; 94(3): 616–640. doi: 10.1080/02772248.2012.657199 PMCID: PMC3346673 3: Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex Arun K. Ghosh, Margherita Brindisi, Prasanth R. Nyalapatla, Jun Takayama, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya Bioorg Med Chem. Author manuscript; available in PMC 2018 Oct 1.Published in final edited form as: Bioorg Med Chem. 2017 Oct 1; 25(19): 5114–5127. Published online 2017 Apr 9. doi: 10.1016/j.bmc.2017.04.005 PMCID: PMC5617771 4: Binding of group 15 and group 16 oxides by a concave host containing an isophthalamide unit Jens Eckelmann, Vittorio Saggiomo, Svenja Fischmann, Ulrich Lüning Beilstein J Org Chem. 2012; 8: 11–17. Published online 2012 Jan 3. doi: 10.3762/bjoc.8.2 PMCID: PMC3302070 5: Efficacy of N,N‘bis-(2-mercaptoethyl) isophthalamide on mercury intoxication: a randomized controlled trial Paul Schutzmeier, Augusto Focil Baquerizo, Wilson Castillo-Tandazo, Nicholas Focil, Stephan Bose-O’Reilly Environ Health. 2018; 17: 15. Published online 2018 Feb 14. doi: 10.1186/s12940-018-0358-1 PMCID: PMC5813329 6: Novel β-CD@ZIF-8 Nanoparticles-Doped Poly(m-phenylene isophthalamide) (PMIA) Thin-Film Nanocomposite (TFN) Membrane for Organic Solvent Nanofiltration (OSN) Sun-Jie Xu, Qian Shen, Gui-E Chen, Zhen-Liang Xu ACS Omega. 2018 Sep 30; 3(9): 11770–11787. Published online 2018 Sep 24. doi: 10.1021/acsomega.8b01808 PMCID: PMC6173514 7: Tailoring Mechanically Robust Poly(m-phenylene isophthalamide) Nanofiber/nets for Ultrathin High-Efficiency Air Filter Shichao Zhang, Hui Liu, Xia Yin, Zhaoling Li, Jianyong Yu, Bin Ding Sci Rep. 2017; 7: 40550. Published online 2017 Jan 11. doi: 10.1038/srep40550 PMCID: PMC5225417 8: Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-l-cysteine, and novel thiol antioxidant, N,N′-bis-2-mercaptoethyl isophthalamide Rishi B. Patel, Sainath R. Kotha, Lynn A. Sauers, Smitha Malireddy, Travis O. Gurney, Niladri N. Gupta, Terry S. Elton, Ulysses J. Magalang, Clay B. Marsh, Boyd E. Haley, Narasimham L. Parinandi Toxicol Mech Methods. Author manuscript; available in PMC 2014 Feb 5.Published in final edited form as: Toxicol Mech Methods. 2012 Jun; 22(5): 383–396. doi: 10.3109/15376516.2012.673089 PMCID: PMC3914546 9: Novel Lipid-Soluble Thiol-Redox Antioxidant and Heavy Metal Chelator, N,N′-bis(2-Mercaptoethyl)Isophthalamide (NBMI) and Phospholipase D-Specific Inhibitor, 5-Fluoro-2-Indolyl Des-Chlorohalopemide (FIPI) Attenuate Mercury-Induced Lipid Signaling Leading to Protection Against Cytotoxicity in Aortic Endothelial Cells Jordan D. Secor, Sainath R. Kotha, Travis O. Gurney, Rishi B. Patel, Nicholas R. Kefauver, Niladri Gupta, Andrew J. Morris, Boyd E. Haley, Narasimham L. Parinandi Int J Toxicol. Author manuscript; available in PMC 2012 Nov 21.Published in final edited form as: Int J Toxicol. 2011 Dec; 30(6): 619–638. Published online 2011 Oct 12. doi: 10.1177/1091581811422413 PMCID: PMC3503146 10: Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands Arun K. Ghosh, Jun Takayama, Luke A. Kassekert, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya Bioorg Med Chem Lett. Author manuscript; available in PMC 2016 Nov 1.Published in final edited form as: Bioorg Med Chem Lett. 2015 Nov 1; 25(21): 4903–4909. Published online 2015 May 30. doi: 10.1016/j.bmcl.2015.05.052 PMCID: PMC4607586 11: catena-Poly[[[aqua­copper(II)]-bis­[μ-N,N′-bis­(pyridin-4-yl)isophthalamide]-[aqua­copper(II)]-di-μ-sulfato] dimethyl­formamide disolvate] Er-Peng Zhang, Li-Ping Wang, Yu-Fei Wang Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 1; 69(Pt 3): m150–m151. Published online 2013 Feb 16. doi: 10.1107/S1600536813003413 PMCID: PMC3588534 12: Conformational control of HCl co-transporter: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine Philip A. Gale, Joachim Garric, Mark E. Light, Beth A. McNally, Bradley D. Smith Chem Commun (Camb) Author manuscript; available in PMC 2010 May 4.Published in final edited form as: Chem Commun (Camb). 2007 May 7; (17): 1736–1738. Published online 2007 Apr 4. doi: 10.1039/b703259e PMCID: PMC2864111 13: Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids Yi-ping Zhu, Kun Xiao, Hai-ping Yu, Lan-ping Ma, Bing Xiong, Hai-yan Zhang, Xin Wang, Jing-ya Li, Jia Li, Jing-kang Shen Acta Pharmacol Sin. 2009 Feb; 30(2): 259–269. Published online 2009 Jan 26. doi: 10.1038/aps.2008.26 PMCID: PMC4002469 14: Design, synthesis, and X-ray structural studies of BACE-1 Inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands Arun K. Ghosh, Margherita Brindisi, Yu-Chen Yen, Emilio L. Cárdenas, Jean-Rene Ella-Menye, Nagaswamy Kumaragurubaran, Xiangping Huang, Jordan Tang, Andrew D. Mesecar Bioorg Med Chem Lett. Author manuscript; available in PMC 2018 Jun 1.Published in final edited form as: Bioorg Med Chem Lett. 2017 Jun 1; 27(11): 2432–2438. Published online 2017 Apr 8. doi: 10.1016/j.bmcl.2017.04.011 PMCID: PMC5479133 15: Influence of Polymethylsilsesquioxane Content to the Thermal Stability of Meta-Aramid Fiber Insulation Paper Wei Zheng, Jufang Xie, Jingwen Zhang, Chao Tang, Zhongyong Zhao Materials (Basel) 2018 Nov; 11(11): 2317. Published online 2018 Nov 19. doi: 10.3390/ma11112317 PMCID: PMC6267194 16: 2,3-Dibutoxynaphthalene-based tetralactam macrocycles for recognizing precious metal chloride complexes Li-Li Wang, Yi-Kuan Tu, Huan Yao, Wei Jiang Beilstein J Org Chem. 2019; 15: 1460–1467. Published online 2019 Jul 2. doi: 10.3762/bjoc.15.146 PMCID: PMC6633862 17: An amide cyclo­phane Vijayan Viswanathan, Ayyavu Thirunarayanan, Perumal Rajakumar, Devadasan Velmurugan Acta Crystallogr Sect E Struct Rep Online. 2014 Aug 1; 70(Pt 8): o865. Published online 2014 Jul 11. doi: 10.1107/S1600536814015621 PMCID: PMC4158555 18: Design and Synthesis of Novel Arylketo-containing P1-P3 Linked Macro-cyclic BACE-1 Inhibitors Veronica Sandgren, Oscar Belda, Ingemar Kvarnström, Jimmy Lindberg, Bertil Samuelsson, Anders Dahlgren Open Med Chem J. 2015; 9: 13–26. Published online 2015 Mar 31. doi: 10.2174/1874104501509010013 PMCID: PMC4412958 19: The Basis for Sensitive and Selective Time-Delayed Luminescence Detection of Hydroxyl Radical by Lanthanide Complexes Katie L. Peterson, Maximilian J. Margherio, Phi Doan, Kyle T. Wilke, Valérie C. Pierre Inorg Chem. Author manuscript; available in PMC 2014 Aug 19.Published in final edited form as: Inorg Chem. 2013 Aug 19; 52(16): 10.1021/ic4009569. Published online 2013 Jul 26. doi: 10.1021/ic4009569 PMCID: PMC3815643 20: Fragment-based Binding Efficiency Indices in Bioactive Molecular Design: A Computational Approach to BACE-1 Inhibitors Nima Razzaghi-Asl, Ahmad Ebadi, Najmeh Edraki, Sara Shahabipour, Ramin Miri Iran J Pharm Res. 2013 Summer; 12(3): 423–436. PMCID: PMC3813291