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MedKoo Cat#: 573844 | Name: Amifostine sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.

Chemical Structure

Amifostine sodium
Amifostine sodium
CAS#59178-37-9 (sodium)

Theoretical Analysis

MedKoo Cat#: 573844

Name: Amifostine sodium

CAS#: 59178-37-9 (sodium)

Chemical Formula: C5H13N2Na2O3PS

Exact Mass: 258.0180

Molecular Weight: 258.18

Elemental Analysis: C, 23.26; H, 5.08; N, 10.85; Na, 17.81; O, 18.59; P, 12.00; S, 12.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
20537-88-6 (free) 112901-68-5 (trihydrate) 59178-37-9 (sodium) 63717-27-1 (monohydrate)
Synonym
Amifostine sodium, WR 2721 sodium, WR2721 sodium, WR-2721 sodium
IUPAC/Chemical Name
Phosphorothioic acid, S-(2-((3-aminopropyl)amino)ethyl) ester, disodium salt
InChi Key
SWWAWQGXMDVHTK-UHFFFAOYSA-L
InChi Code
1S/C5H15N2O3PS.2Na/c6-2-1-3-7-4-5-12-11(8,9)10;;/h7H,1-6H2,(H2,8,9,10);;/q;2*+1/p-2
SMILES Code
[Na+].[Na+].NCCCNCCSP(=O)([O-])[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 258.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jaćević V, Dragojević-Simić V, Tatomirović Ž, Dobrić S, Bokonjić D, Kovačević A, Nepovimova E, Vališ M, Kuča K. The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats. Int J Mol Sci. 2018 Aug 12;19(8). pii: E2370. doi: 10.3390/ijms19082370. PubMed PMID: 30103540. 2: Sueishi Y, Nii R. Monoterpene's multiple free radical scavenging capacity as compared with the radioprotective agent cysteamine and amifostine. Bioorg Med Chem Lett. 2018 Aug 2. pii: S0960-894X(18)30652-8. doi: 10.1016/j.bmcl.2018.08.003. [Epub ahead of print] PubMed PMID: 30098868.

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3HAO-IN-I3

3HAO-IN-I3