S-(3-Carboxypropyl)-L-cysteine | CAS# 30845-11-5 | Biochemical

MedKoo Cat#: 573824 | Name: S-(3-Carboxypropyl)-L-cysteine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine.

Chemical Structure

S-(3-Carboxypropyl)-L-cysteine

CAS#30845-11-5

Theoretical Analysis

MedKoo Cat#: 573824

Name: S-(3-Carboxypropyl)-L-cysteine

CAS#: 30845-11-5

Chemical Formula: C7H13NO4S

Exact Mass: 207.0565

Molecular Weight: 207.24

Elemental Analysis: C, 40.57; H, 6.32; N, 6.76; O, 30.88; S, 15.47

Price and Availability

Size	Price	Availability
10mg	USD 90.00	Ready to ship
25mg	USD 150.00	Ready to ship
50mg	USD 250.00	Ready to ship
100mg	USD 450.00	Ready to ship
200mg	USD 750.00	Ready to ship

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Synonym

S-(3-Carboxypropyl)-L-cysteine; S-3-CARBOXYPROPYL-L-CYSTEINE

IUPAC/Chemical Name

(R)-4-[(2-Amino-2-carboxyethyl)thio]butanoic Acid

InChi Key

WNFNRNDFHINZLV-YFKPBYRVSA-N

InChi Code

InChI=1S/C7H13NO4S/c8-5(7(11)12)4-13-3-1-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)/t5-/m0/s1

SMILES Code

O=C(O)CCCSC[C@H](N)C(O)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#A22T07K11

QC Data

View QC data: current batch, Lot#A22T07K11

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine.

In vitro activity:

CPC was a competitive inhibitor with respect to both cystathionine and cysteine in the canonical and H2S synthesis reactions, respectively. The lower Ki value in the cystathionine (50 ± 3 μm) versus cysteine (180 ± 15 μm) cleavage assay suggests that CPC competes more effectively against the longer cystathionine versus the shorter cysteine substrate. The Kd(app) for CPC binding to CSE was 26 ± 3 μm. In cell culture, CPC inhibited the transsulfuration flux, an indicator of the canonical CSE reaction; ≥80% inhibition was observed in HepG2 cells at a concentration of 2.5 mm CPC (Fig. 5A). Reference: J Biol Chem. 2019 Jul 12;294(28):11011-11022. https://pubmed.ncbi.nlm.nih.gov/31160338/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 207.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis. J Biol Chem. 2019 Jul 12;294(28):11011-11022. doi: 10.1074/jbc.RA119.009047. Epub 2019 Jun 3. PMID: 31160338; PMCID: PMC6635441.

In vitro protocol:

In vivo protocol:

TBD

1: Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis. J Biol Chem. 2019 Jul 12;294(28):11011-11022. doi: 10.1074/jbc.RA119.009047. Epub 2019 Jun 3. PubMed PMID: 31160338; PubMed Central PMCID: PMC6635441.