T-2 Toxin | CAS#21259-20-1 | cytotoxic fungal

MedKoo Cat#: 126050 | Name: T-2 toxin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium.

Chemical Structure

T-2 toxin

CAS#21259-20-1

Theoretical Analysis

MedKoo Cat#: 126050

Name: T-2 toxin

CAS#: 21259-20-1

Chemical Formula: C24H34O9

Exact Mass: 466.2203

Molecular Weight: 466.53

Elemental Analysis: C, 61.79; H, 7.35; O, 30.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

T-2 TOXIN; T2 Toxin; T2-Trichothecene; Mycotoxin T-2; Insariotoxin; Isaritoxin; T-2 mycotoxin; Fusariotoxine T2; Fusariotoxin T-2; Toxin T2; Fusariotoxin T 2

IUPAC/Chemical Name

(2S,2'R,3'R,4'S,5'S,5a'R,7'S,9a'R)-4'-acetoxy-5a'-(acetoxymethyl)-3'-hydroxy-5',8'-dimethyl-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-7'-yl 3-methylbutanoate

InChi Key

BXFOFFBJRFZBQZ-QYWOHJEZSA-N

InChi Code

InChI=1S/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1

SMILES Code

[H][C@@]12O[C@]3([H])C=C(C)[C@H](C[C@]3(COC(C)=O)[C@@](C)([C@H](OC(C)=O)[C@H]1O)[C@]24CO4)OC(=O)CC(C)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 466.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Song W, Wang Y, Huang T, Liu Y, Chen F, Chen Y, Jiang Y, Zhang C, Yang X. T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification. Environ Pollut. 2023 Aug 1;330:121784. doi: 10.1016/j.envpol.2023.121784. Epub 2023 May 9. PMID: 37169237. 2: Janik E, Niemcewicz M, Podogrocki M, Ceremuga M, Stela M, Bijak M. T-2 Toxin- The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies. Molecules. 2021 Nov 14;26(22):6868. doi: 10.3390/molecules26226868. PMID: 34833960; PMCID: PMC8618548. 3: Dai C, Das Gupta S, Wang Z, Jiang H, Velkov T, Shen J. T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications. Food Chem Toxicol. 2022 Sep;167:113262. doi: 10.1016/j.fct.2022.113262. Epub 2022 Jul 2. PMID: 35792220. 4: Li SJ, Zhang G, Xue B, Ding Q, Han L, Huang JC, Wu F, Li C, Yang C. Toxicity and detoxification of T-2 toxin in poultry. Food Chem Toxicol. 2022 Nov;169:113392. doi: 10.1016/j.fct.2022.113392. Epub 2022 Aug 28. PMID: 36044934. 5: Yang X, Liu P, Cui Y, Xiao B, Liu M, Song M, Huang W, Li Y. Review of the Reproductive Toxicity of T-2 Toxin. J Agric Food Chem. 2020 Jan 22;68(3):727-734. doi: 10.1021/acs.jafc.9b07880. Epub 2020 Jan 8. PMID: 31895560. 6: Wu Q, Qin Z, Kuca K, You L, Zhao Y, Liu A, Musilek K, Chrienova Z, Nepovimova E, Oleksak P, Wu W, Wang X. An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment. Arch Toxicol. 2020 Nov;94(11):3645-3669. doi: 10.1007/s00204-020-02899-9. Epub 2020 Sep 10. PMID: 32910237. 7: Li Y, Wang Z, Beier RC, Shen J, De Smet D, De Saeger S, Zhang S. T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods. J Agric Food Chem. 2011 Apr 27;59(8):3441-53. doi: 10.1021/jf200767q. Epub 2011 Mar 25. PMID: 21417259. 8: Wang C, He J, Jin H, Xiao H, Peng S, Xie J, Zhang L, Guo J. T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1. Chemosphere. 2023 Nov;341:140087. doi: 10.1016/j.chemosphere.2023.140087. Epub 2023 Sep 5. PMID: 37678596. 9: Li J, Wang Y, Deng Y, Wang X, Wu W, Nepovimova E, Wu Q, Kuca K. Toxic mechanisms of the trichothecenes T-2 toxin and deoxynivalenol on protein synthesis. Food Chem Toxicol. 2022 Jun;164:113044. doi: 10.1016/j.fct.2022.113044. Epub 2022 Apr 19. PMID: 35452771. 10: Zhang J, Wang P, Song M, Zhang X, Huo S, Du J, Li B, Cao Z, Li Y. T-2 toxin inhibits osteoblastic differentiation and mineralization involving mutual regulation between Wnt signaling pathway and autophagy. Chem Biol Interact. 2023 Jan 5;369:110266. doi: 10.1016/j.cbi.2022.110266. Epub 2022 Nov 17. PMID: 36402210.