Synonym
Mitratapide; R103757; R 103757; R-103757
IUPAC/Chemical Name
2-((2R)-Butan-2-yl)-4-(4-(4-(4-(((2S,4R)-2-(4-chlorophenyl)-2-((4-methyl-4H-1,2,4-triazol-3-ylsulfanyl)methyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
InChi Key
HQSRVYUCBOCBLY-XOOFNSLWSA-N
InChi Code
InChI=1S/C36H41ClN8O4S/c1-4-26(2)45-35(46)44(25-39-45)31-11-9-29(10-12-31)42-17-19-43(20-18-42)30-13-15-32(16-14-30)47-21-33-22-48-36(49-33,27-5-7-28(37)8-6-27)23-50-34-40-38-24-41(34)3/h5-16,24-26,33H,4,17-23H2,1-3H3/t26-,33-,36-/m1/s1
SMILES Code
O=C1N([C@@H](CC)C)N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@H]5O[C@](CSC6=NN=CN6C)(C7=CC=C(Cl)C=C7)OC5)C=C4)CC3)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
717.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Peña C, Suarez L, Bautista-Castaño I, Juste MC, Carretón E, Montoya-Alonso JA. Effects of low-fat high-fibre diet and mitratapide on body weight reduction, blood pressure and metabolic parameters in obese dogs. J Vet Med Sci. 2014 Sep;76(9):1305-8. Epub 2014 Jun 11. PubMed PMID: 24920548; PubMed Central PMCID: PMC4197164.
2: Dobenecker B, De Bock M, Engelen M, Goossens L, Scholz A, Kienzle E. Effect of mitratapide on body composition, body measurements and glucose tolerance in obese Beagles. Vet Res Commun. 2009 Dec;33(8):839-47. doi: 10.1007/s11259-009-9232-5. PubMed PMID: 19544001; PubMed Central PMCID: PMC2776940.
3: Verreck G, Vandecruys R, De Conde V, Baert L, Peeters J, Brewster ME. The use of three different solid dispersion formulations--melt extrusion, film-coated beads, and a glass thermoplastic system--to improve the bioavailability of a novel microsomal triglyceride transfer protein inhibitor. J Pharm Sci. 2004 May;93(5):1217-28. PubMed PMID: 15067698.
