MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 564988 | Name: MJ-15
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MJ-15 is a potent and selective antagonist of cannabinoid CB1 receptor.

Chemical Structure

MJ-15
MJ-15
CAS#944154-76-1

Theoretical Analysis

MedKoo Cat#: 564988

Name: MJ-15

CAS#: 944154-76-1

Chemical Formula: C23H17Cl3N4O

Exact Mass: 470.0468

Molecular Weight: 471.77

Elemental Analysis: C, 58.56; H, 3.63; Cl, 22.54; N, 11.88; O, 3.39

Price and Availability

Size Price Availability Quantity
5mg USD 385.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
MJ15; MJ 15; MJ-15
IUPAC/Chemical Name
5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(pyridin-3-ylmethyl)pyrazole-3-carboxamide
InChi Key
PJEIKJFNEFJFLA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H17Cl3N4O/c1-14-21(23(31)28-13-15-3-2-10-27-12-15)29-30(20-9-8-18(25)11-19(20)26)22(14)16-4-6-17(24)7-5-16/h2-12H,13H2,1H3,(H,28,31)
SMILES Code
O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Cl)C=C3)=C1C)NCC4=CC=CN=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors.
In vitro activity:
In addition, MJ15 dose-dependently blocked Win55212-2 mediated increase of intracellular Ca(2+) levels in hippocampal cells and reversed the inhibitory effects of cannabinoid CB(1) receptor agonist on forskolin-stimulated adenylyl cyclase activity in CHO cells expressing the human cannabinoid CB(1) receptor. Reference: Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85. https://pubmed.ncbi.nlm.nih.gov/20380831/
In vivo activity:
In animal experiments, MJ15 demonstrated remarkable effects from 20 to 40 mg/kg, including promoted the small intestine peristalsis in ICR mice and inhibited food intake and body weight increase in diet-induced obesity (DIO) rat and mouse. 40 mg/kg MJ15 significantly reduced food intake at initial 2 weeks of treatment, prevented the increase of body weight and adipose by 46% and 28% respectively in DIO rats, and reduced body weight and adipose gain by 70% and 23% respectively in early onset obesity DIO mice after 4 weeks treatment. Reference: Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85. https://pubmed.ncbi.nlm.nih.gov/20380831/

Preparing Stock Solutions

The following data is based on the product molecular weight 471.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Chen W, Tang H, Liu H, Long L, Gong Z, Zheng J, Chi M, Xie Y, Zheng Z, Li S, Wang L. Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85. doi: 10.1016/j.ejphar.2010.03.040. Epub 2010 Apr 7. PMID: 20380831.
In vitro protocol:
Chen W, Tang H, Liu H, Long L, Gong Z, Zheng J, Chi M, Xie Y, Zheng Z, Li S, Wang L. Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85. doi: 10.1016/j.ejphar.2010.03.040. Epub 2010 Apr 7. PMID: 20380831.
In vivo protocol:
Chen W, Tang H, Liu H, Long L, Gong Z, Zheng J, Chi M, Xie Y, Zheng Z, Li S, Wang L. Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85. doi: 10.1016/j.ejphar.2010.03.040. Epub 2010 Apr 7. PMID: 20380831.
1: Chen W, Tang H, Liu H, Long L, Gong Z, Zheng J, Chi M, Xie Y, Zheng Z, Li S, Wang L. Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85. doi: 10.1016/j.ejphar.2010.03.040. Epub 2010 Apr 7. PubMed PMID: 20380831.

View History

Bis-PEG3-thiol

Bis-PEG3-thiol