MedKoo Cat#: 558686 | Name: AK963

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AK963, also known as 40708899, is a potent PAK1 (p21-activated kinase 1) inhibitor, which suppresses the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway.

Chemical Structure

AK963
AK963
CAS#445007-59-0

Theoretical Analysis

MedKoo Cat#: 558686

Name: AK963

CAS#: 445007-59-0

Chemical Formula: C16H18N2O

Exact Mass: 254.1419

Molecular Weight: 254.33

Elemental Analysis: C, 75.56; H, 7.13; N, 11.01; O, 6.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AK-963; AK 963; AK963; 40708899
IUPAC/Chemical Name
1-(2,5-Dimethylphenyl)-3-(3-methylphenyl)urea
InChi Key
BAIIKMBZYOWCBK-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H18N2O/c1-11-5-4-6-14(9-11)17-16(19)18-15-10-12(2)7-8-13(15)3/h4-10H,1-3H3,(H2,17,18,19)
SMILES Code
O=C(NC1=CC=CC(C)=C1)NC2=CC(C)=CC=C2C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 254.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou Y, Zhang J, Wang J, Cheng MS, Zhao DM, Li F. Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1-Related Signaling Pathways. Anat Rec (Hoboken). 2019 Sep;302(9):1571-1579. doi: 10.1002/ar.24095. Epub 2019 Mar 27. PubMed PMID: 30773850.