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MedKoo Cat#: 573818 | Name: Amopyroquine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amopyroquine hydrochloride is a biochemical with anticholinesterase activity.

Chemical Structure

Amopyroquine hydrochloride
Amopyroquine hydrochloride
CAS#10350-81-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 573818

Name: Amopyroquine hydrochloride

CAS#: 10350-81-9 (HCl)

Chemical Formula: C20H22Cl3N3O

Exact Mass: 425.0828

Molecular Weight: 426.77

Elemental Analysis: C, 56.29; H, 5.20; Cl, 24.92; N, 9.85; O, 3.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
10350-81-9 (HCl) 550-81-2 (free base)
Synonym
Amopyroquin dihydrochloride, Amopyroquine hydrochloride, Amopyroquine HCl, Propoquin
IUPAC/Chemical Name
o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-, dihydrochloride
InChi Key
ZIROSOHFLOYBBU-UHFFFAOYSA-N
InChi Code
1S/C20H20ClN3O.2ClH/c21-15-3-5-17-18(7-8-22-19(17)12-15)23-16-4-6-20(25)14(11-16)13-24-9-1-2-10-24;;/h3-8,11-12,25H,1-2,9-10,13H2,(H,22,23);2*1H
SMILES Code
c12c(Nc3cc(CN4CCCC4)c(O)cc3)ccnc1cc(Cl)cc2.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 426.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Le Fur N, Hochart G, Larchanché PE, Melnyk P. Buchwald reaction as the key step for the synthesis of metabolically more stable analogs of amodiaquine. Eur J Med Chem. 2011 Jul;46(7):3052-7. doi: 10.1016/j.ejmech.2011.04.047. Epub 2011 Apr 21. PubMed PMID: 21565435. 2: Păunescu E, Susplugas S, Boll E, Varga R, Mouray E, Grosu I, Grellier P, Melnyk P. Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity. ChemMedChem. 2009 Apr;4(4):549-61. doi: 10.1002/cmdc.200800318. PubMed PMID: 19212949. 3: Paunescu E, Susplugas S, Boll E, Varga RA, Mouray E, Grellier P, Melnyk P. Synthesis and antimalarial activity of new amino analogues of amodiaquine. Med Chem. 2008 Sep;4(5):407-25. PubMed PMID: 18782038.