T1001 is an antagonist of hypoxia-inducible factor-2α subunit (HIF-2α) which displaces residue M252 from inside the HIF-2α PAS-B pocket toward the ARNT subunit to weaken heterodimerization.
MedKoo Cat#: 558663
Name: T1001
CAS#: 56943-06-7
Chemical Formula: C11H11BrN2S
Exact Mass: 281.9826
Molecular Weight: 283.19
Elemental Analysis: C, 46.66; H, 3.92; Br, 28.22; N, 9.89; S, 11.32
The following data is based on the product molecular weight 283.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
