AMG-837 sodium is a salt of AMG-837 --- a potent GPR40 agonist. Acute administration of AMG-837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG-837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG-837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG-837 for the treatment of type 2 diabetes.
MedKoo Cat#: 573786
Name: AMG-837 sodium
CAS#: 865231-45-4 (sodium)
Chemical Formula: C26H20F3NaO3
Exact Mass: 460.1262
Molecular Weight: 460.43
Elemental Analysis: C, 67.83; H, 4.38; F, 12.38; Na, 4.99; O, 10.42
The following data is based on the product molecular weight 460.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
