Synonym
ER-38925; ER 38925; ER38925
IUPAC/Chemical Name
4-(5-(4,7-Dimethylbenzofuran-2-yl)-1H-pyrrol-2-yl)benzoic acid
InChi Key
LSZNZLWBRQAWNH-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H17NO3/c1-12-3-4-13(2)20-16(12)11-19(25-20)18-10-9-17(22-18)14-5-7-15(8-6-14)21(23)24/h3-11,22H,1-2H3,(H,23,24)
SMILES Code
O=C(O)C1=CC=C(C2=CC=C(C3=CC4=C(C)C=CC(C)=C4O3)N2)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
331.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hida T, Shikata K, Tokuhara N, Ishibashi A, Nagai M, Yamauchi T, Kobayashi S. Immunosuppressive effect of ER-38925, a retinoic acid receptor subtype α-selective agonist, in mouse models of human graft-vs-host disease. Drug Discov Ther. 2008 Feb;2(1):35-44. PubMed PMID: 22504453.
2: Seino K, Yamauchi T, Shikata K, Kobayashi S, Nagai M, Taniguchi M, Fukao K. Prevention of acute and chronic allograft rejection by a novel retinoic acid receptor-alpha-selective agonist. Int Immunol. 2004 May;16(5):665-73. Epub 2004 Mar 29. Erratum in: Int Immunol. 2004 Jul;16(7):1053. PubMed PMID: 15096490.
3: Yoshimura K, Uchida G, Okazaki M, Kitano Y, Harii K. Differential expression of heparin-binding EGF-like growth factor (HB-EGF) mRNA in normal human keratinocytes induced by a variety of natural and synthetic retinoids. Exp Dermatol. 2003;12 Suppl 2:28-34. PubMed PMID: 14756521.
4: Seino K, Yamauchi T, Ishibashi A, Tokuhara N, Kobayashi S, Fukunaga K, Taniguchi H, Takada Y, Yuzawa K, Otsuka M, Todoroki T, Fukao K. Prolongation of mouse skin allograft survival by novel agonists selective for retinoic acid receptor-alpha. Transplant Proc. 2000 Mar;32(2):257-8. PubMed PMID: 10715409.
5: Yoshimura H, Kikuchi K, Hibi S, Tagami K, Satoh T, Yamauchi T, Ishibahi A, Tai K, Hida T, Tokuhara N, Nagai M. Discovery of novel and potent retinoic acid receptor alpha agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives. J Med Chem. 2000 Jul 27;43(15):2929-37. PubMed PMID: 10956201.
