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MedKoo Cat#: 573758 | Name: Algestone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Algestone is a synthetic progestational dihydroxy derivative of Progesterone. The acetonide group possesses anti-inflammatory properties.

Chemical Structure

Algestone
Algestone
CAS#595-77-7

Theoretical Analysis

MedKoo Cat#: 573758

Name: Algestone

CAS#: 595-77-7

Chemical Formula: C21H30O4

Exact Mass: 346.2144

Molecular Weight: 346.47

Elemental Analysis: C, 72.80; H, 8.73; O, 18.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Algestone, Alphasone
IUPAC/Chemical Name
16alpha,17-Dihydroxypregn-4-ene-3,20-dione
InChi Key
CXDWHYOBSJTRJU-SRWWVFQWSA-N
InChi Code
1S/C21H30O4/c1-12(22)21(25)18(24)11-17-15-5-4-13-10-14(23)6-8-19(13,2)16(15)7-9-20(17,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16+,17+,18-,19+,20+,21-/m1/s1
SMILES Code
CC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Melting Point: 225 degC (EXP) log P (octanol-water): 3.150 (EST) Atmospheric OH Rate Constant: 1.21E-10 cm3/molecule-sec25 (EST)

Preparing Stock Solutions

The following data is based on the product molecular weight 346.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gent R, du Toit T, Swart AC. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro. J Steroid Biochem Mol Biol. 2019 Jul;191:105369. doi: 10.1016/j.jsbmb.2019.04.018. Epub 2019 Apr 27. PubMed PMID: 31039398. 2: Zhu Y, Liu D, Shaner ZC, Chen S, Hong W, Stellwag EJ. Nuclear progestin receptor (pgr) knockouts in zebrafish demonstrate role for pgr in ovulation but not in rapid non-genomic steroid mediated meiosis resumption. Front Endocrinol (Lausanne). 2015 Mar 19;6:37. doi: 10.3389/fendo.2015.00037. eCollection 2015. PubMed PMID: 25852646; PubMed Central PMCID: PMC4365747. 3: Gallo MF, Grimes DA, Lopez LM, Schulz KF, d'Arcangues C. Combination injectable contraceptives for contraception. Cochrane Database Syst Rev. 2013;3:CD004568. Review. PubMed PMID: 23641480.