MedKoo Cat#: 565656 | Name: Bragsin2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bragsin2 is a novel specific inhibitor of the arfgef brag2, targeting the ph domain of brag2 in vitro and in cells, affecting arf pathways in cells and inhibiting brag2-mediated arf gtpase activation in vitro in a manner that requires a membrane

Chemical Structure

Bragsin2
Bragsin2
CAS#342795-08-8

Theoretical Analysis

MedKoo Cat#: 565656

Name: Bragsin2

CAS#: 342795-08-8

Chemical Formula: C11H6F3NO5

Exact Mass: 289.0198

Molecular Weight: 289.17

Elemental Analysis: C, 45.69; H, 2.09; F, 19.71; N, 4.84; O, 27.66

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,350.00 2 Weeks
200mg USD 2,350.00 2 Weeks
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Related CAS #
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Synonym
Bragsin2; Bragsin-2; Bragsin 2
IUPAC/Chemical Name
6-Methoxy-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one
InChi Key
WJUILHMXVGFAIS-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H6F3NO5/c1-19-7-3-2-6-9(10(7)15(17)18)5(16)4-8(20-6)11(12,13)14/h2-4H,1H3
SMILES Code
O=C1C=C(C(F)(F)F)OC2=C1C([N+]([O-])=O)=C(OC)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 289.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Apr;15(4):358-366. doi: 10.1038/s41589-019-0228-3. Epub 2019 Feb 11. Erratum in: Nat Chem Biol. 2019 May;15(5):549. doi: 10.1038/s41589-019-0255-0. PMID: 30742123.