SC 19886 | CAS#22785-18-8 | antimineralocorticoid

MedKoo Cat#: 461856 | Name: SC 19886

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC 19886 is an antimineralocorticoid that acts as a potent inhibitor of aldosterone biosynthesis.

Chemical Structure

SC 19886

CAS#22785-18-8

Theoretical Analysis

MedKoo Cat#: 461856

Name: SC 19886

CAS#: 22785-18-8

Chemical Formula: C19H26O2

Exact Mass: 286.1933

Molecular Weight: 286.41

Elemental Analysis: C, 79.68; H, 9.15; O, 11.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SC 19886; SC-19886; SC19886;

IUPAC/Chemical Name

(6aS,6bS,10R,10aR,11aR,11bR)-10,11b-dimethyl-1,5,6,6a,6b,7,8,10,10a,11,11a,11b-dodecahydro-3H-benzo[a]fluorene-3,9(2H)-dione

InChi Key

QKJVUGLHJLJREL-LPPIKFRJSA-N

InChi Code

InChI=1S/C19H26O2/c1-11-16-10-17-15(14(16)5-6-18(11)21)4-3-12-9-13(20)7-8-19(12,17)2/h9,11,14-17H,3-8,10H2,1-2H3/t11-,14+,15+,16+,17-,19+/m1/s1

SMILES Code

O=C(CC1)[C@H](C)[C@H]2[C@@H]1[C@@H]3CCC4=CC(CC[C@]4(C)[C@@H]3C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 286.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Netchitailo P, Delarue C, Perroteau I, Leboulenger F, Capron MH, Vaudry H. Relative inhibitory potency of five mineralocorticoid antagonists on aldosterone biosynthesis in vitro. Biochem Pharmacol. 1985 Jan 15;34(2):189-94. PubMed PMID: 2981534. 2: Netchitailo P, Perroteau I, Delarue C, Leboulenger F, Capron MH, Vaudry H. [Direct action of mineralocorticoid antagonists on biosynthesis of aldosterone: comparative activities of several new compounds]. Can J Physiol Pharmacol. 1983 Jan;61(1):23-8. French. PubMed PMID: 6301660. 3: Corvol P, Claire M, Oblin ME, Geering K, Rossier B. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney Int. 1981 Jul;20(1):1-6. Review. PubMed PMID: 7029118.