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MedKoo Cat#: 564234 | Name: Bimosiamose Disodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bimosiamose Disodium is a Pan-selectin antagonist developed for the treatment of acute and chronic inflammatory disorders.

Chemical Structure

Bimosiamose Disodium
Bimosiamose Disodium
CAS#187269-60-9 (disodium)

Theoretical Analysis

MedKoo Cat#: 564234

Name: Bimosiamose Disodium

CAS#: 187269-60-9 (disodium)

Chemical Formula: C46H52Na2O16

Exact Mass: 0.0000

Molecular Weight: 906.89

Elemental Analysis: C, 60.92; H, 5.78; Na, 5.07; O, 28.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
187269-40-5 (free acid) 187269-60-9 (disodium)
Synonym
TBC1269z; TBC-1269z; TBC 1269z; Bimosiamose Disodium
IUPAC/Chemical Name
Disodium 2-[3-[5-[6-[3-[3-(carboxymethyl)phenyl]-4-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]hexyl]-2-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]phenyl]acetate
InChi Key
ZGEPTUZKSXWWAB-PNGDFCJYSA-L
InChi Code
InChI=1S/C46H54O16.2Na/c47-23-35-39(53)41(55)43(57)45(61-35)59-33-15-13-25(19-31(33)29-11-5-9-27(17-29)21-37(49)50)7-3-1-2-4-8-26-14-16-34(60-46-44(58)42(56)40(54)36(24-48)62-46)32(20-26)30-12-6-10-28(18-30)22-38(51)52;;/h5-6,9-20,35-36,39-48,53-58H,1-4,7-8,21-24H2,(H,49,50)(H,51,52);;/q;2*+1/p-2/t35-,36-,39-,40-,41+,42+,43+,44+,45+,46+;;/m1../s1
SMILES Code
O=C([O-])CC1=CC=CC(C2=CC(CCCCCCC3=CC=C(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)C(C5=CC=CC(CC([O-])=O)=C5)=C3)=CC=C2O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)=C1.[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 906.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Meyer M, Jilma B, Zahlten R, Wolff G. Physiochemical properties, safety and pharmacokinetics of bimosiamose disodium after intravenous administration. Int J Clin Pharmacol Ther. 2005 Oct;43(10):463-71. PubMed PMID: 16240703. 2: Meyer M, Beyer D, Vollhardt K, Woischwill C, Jilma B, Wolff G. The pharmacokinetics of subcutaneously injected Bimosiamose disodium in healthy male volunteers. Biopharm Drug Dispos. 2007 Dec;28(9):475-84. PubMed PMID: 17876866. 3: Meyer M, Beeh KM, Beier J, Beyer D, Aydt E, Zahlten R, Jilma B, Wolff G. Tolerability and pharmacokinetics of inhaled bimosiamose disodium in healthy males. Br J Clin Pharmacol. 2007 Apr;63(4):451-8. Epub 2006 Sep 20. PubMed PMID: 17067318; PubMed Central PMCID: PMC2203253.