MedKoo Cat#: 565574 | Name: 103D5R

Description:

WARNING: This product is for research use only, not for human or veterinary use.

103D5R is a novel selective inhibitor of hif-1α, markedly decreasing hif-1α protein levels induced by hypoxia or cobaltous ions in a dose- and time-dependent manner

Chemical Structure

103D5R
103D5R
CAS#773852-25-8

Theoretical Analysis

MedKoo Cat#: 565574

Name: 103D5R

CAS#: 773852-25-8

Chemical Formula: C20H21N3O2

Exact Mass: 335.1634

Molecular Weight: 335.41

Elemental Analysis: C, 71.62; H, 6.31; N, 12.53; O, 9.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
103D5R; 103 103 5; 103-103-5
IUPAC/Chemical Name
1-(1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)ethyl)-1H-imidazo[4,5-b]pyridine
InChi Key
MCVWPJZBARCDLJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21N3O2/c1-13(23-12-22-19-16(23)6-5-11-21-19)14-7-8-17-15(18(14)24-4)9-10-20(2,3)25-17/h5-13H,1-4H3
SMILES Code
CC(N1C=NC2=NC=CC=C21)C3=C(OC)C(C=CC(C)(C)O4)=C4C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 335.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Belozerov VE, Van Meir EG. Hypoxia inducible factor-1: a novel target for cancer therapy. Anticancer Drugs. 2005 Oct;16(9):901-9. Review. PubMed PMID: 16162966. 2: Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, Van Meir EG. Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Res. 2005 Jan 15;65(2):605-12. PubMed PMID: 15695405.