HS220| CAS#N/A| inhibitor| MedKoo

MedKoo Cat#: 565513 | Name: HS220

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HS220 is a novel inhibitor of p. falciparum protein kinase 9 (pfpk9), decreasing k63-linked ubiquitination in p. falciparum

Chemical Structure

HS220

CAS#CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565513

Name: HS220

CAS#: CAS#N/A

Chemical Formula: C18H17N3O3

Exact Mass: 323.1270

Molecular Weight: 323.35

Elemental Analysis: C, 66.86; H, 5.30; N, 13.00; O, 14.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HS220; HS 220; HS-220

IUPAC/Chemical Name

3-((1-Propyl-1H-benzo[d]imidazol-2-yl)carbamoyl)benzoic acid

InChi Key

OWYWEJQTFNMMSF-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H17N3O3/c1-2-10-21-15-9-4-3-8-14(15)19-18(21)20-16(22)12-6-5-7-13(11-12)17(23)24/h3-9,11H,2,10H2,1H3,(H,23,24)(H,19,20,22)

SMILES Code

O=C(O)C1=CC=CC(C(NC2=NC3=CC=CC=C3N2CCC)=O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 323.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thomas TH, Harkin DJ, Gillett AJ, Lemaur V, Nikolka M, Sadhanala A, Richter JM, Armitage J, Chen H, McCulloch I, Menke SM, Olivier Y, Beljonne D, Sirringhaus H. Short contacts between chains enhancing luminescence quantum yields and carrier mobilities in conjugated copolymers. Nat Commun. 2019 Jun 13;10(1):2614. doi: 10.1038/s41467-019-10277-y. PubMed PMID: 31197152; PubMed Central PMCID: PMC6565747. 2: Nikolka M, Broch K, Armitage J, Hanifi D, Nowack PJ, Venkateshvaran D, Sadhanala A, Saska J, Mascal M, Jung SH, Lee JK, McCulloch I, Salleo A, Sirringhaus H. High-mobility, trap-free charge transport in conjugated polymer diodes. Nat Commun. 2019 May 9;10(1):2122. doi: 10.1038/s41467-019-10188-y. PubMed PMID: 31073179; PubMed Central PMCID: PMC6509340. 3: Ban M, Zou Y, Rivett JPH, Yang Y, Thomas TH, Tan Y, Song T, Gao X, Credgington D, Deschler F, Sirringhaus H, Sun B. Author Correction: Solution-processed perovskite light emitting diodes with efficiency exceeding 15% through additive-controlled nanostructure tailoring. Nat Commun. 2019 Feb 22;10(1):962. doi: 10.1038/s41467-019-09013-3. PubMed PMID: 30796250; PubMed Central PMCID: PMC6385192. 4: Raphemot R, Eubanks AL, Toro-Moreno M, Geiger RA, Hughes PF, Lu KY, Haystead TAJ, Derbyshire ER. Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. Cell Chem Biol. 2019 Mar 21;26(3):411-419.e7. doi: 10.1016/j.chembiol.2018.11.003. Epub 2018 Dec 27. PubMed PMID: 30595530; PubMed Central PMCID: PMC6430656. 5: Ban M, Zou Y, Rivett JPH, Yang Y, Thomas TH, Tan Y, Song T, Gao X, Credgington D, Deschler F, Sirringhaus H, Sun B. Solution-processed perovskite light emitting diodes with efficiency exceeding 15% through additive-controlled nanostructure tailoring. Nat Commun. 2018 Sep 24;9(1):3892. doi: 10.1038/s41467-018-06425-5. Erratum in: Nat Commun. 2019 Feb 22;10(1):962. PubMed PMID: 30250032; PubMed Central PMCID: PMC6155305. 6: Shi Y, Jiang L, Liu J, Tu Z, Hu Y, Wu Q, Yi Y, Gann E, McNeill CR, Li H, Hu W, Zhu D, Sirringhaus H. Bottom-up growth of n-type monolayer molecular crystals on polymeric substrate for optoelectronic device applications. Nat Commun. 2018 Jul 26;9(1):2933. doi: 10.1038/s41467-018-05390-3. PubMed PMID: 30050114; PubMed Central PMCID: PMC6062560. 7: Banger K, Warwick C, Lang J, Broch K, Halpert JE, Socratous J, Brown A, Leedham T, Sirringhaus H. Identification of dipole disorder in low temperature solution processed oxides: its utility and suppression for transparent high performance solution-processed hybrid electronics. Chem Sci. 2016 Oct 1;7(10):6337-6346. doi: 10.1039/c6sc01962e. Epub 2016 Jul 11. PubMed PMID: 28567246; PubMed Central PMCID: PMC5450438. 8: Gruber M, Jung SH, Schott S, Venkateshvaran D, Kronemeijer AJ, Andreasen JW, McNeill CR, Wong WWH, Shahid M, Heeney M, Lee JK, Sirringhaus H. Enabling high-mobility, ambipolar charge-transport in a DPP-benzotriazole copolymer by side-chain engineering. Chem Sci. 2015 Dec 1;6(12):6949-6960. doi: 10.1039/c5sc01326g. Epub 2015 Aug 12. PubMed PMID: 29861933; PubMed Central PMCID: PMC5951104. 9: Sirringhaus H, Kawase T, Friend RH, Shimoda T, Inbasekaran M, Wu W, Woo EP. High-resolution inkjet printing of all-polymer transistor circuits. Science. 2000 Dec 15;290(5499):2123-6. PubMed PMID: 11118142.