MedKoo Cat#: 591215 | Name: L-Phenylephrine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Phenylephrine is an alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.

Chemical Structure

L-Phenylephrine
L-Phenylephrine
CAS#614-03-9

Theoretical Analysis

MedKoo Cat#: 591215

Name: L-Phenylephrine

CAS#: 614-03-9

Chemical Formula: C9H13NO2

Exact Mass: 167.0946

Molecular Weight: 167.21

Elemental Analysis: C, 64.65; H, 7.84; N, 8.38; O, 19.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
L-Phenylephrine, Phenylephrine, (S)-
IUPAC/Chemical Name
(S)-3-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol
InChi Key
SONNWYBIRXJNDC-SECBINFHSA-N
InChi Code
1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m1/s1
SMILES Code
c1([C@@H](CNC)O)cc(ccc1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 167.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takenouchi Y, Ohtake K, Nobe K, Kasono K. Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice. Lipids Health Dis. 2018 May 22;17(1):118. doi: 10.1186/s12944-018-0770-0. PubMed PMID: 29788974. 2: Orbach-Zinger S, Razinsky E, Bizman I, Firman S, Gat R, Davis A, Ashwal E, Shmueli A, Vaturi M, Gabbay-Benziv R, Eidelman LA. Perioperative noninvasive cardiac output monitoring in parturients with singleton and twin pregnancies undergoing caesarean section under spinal anesthesia with prophylactic phenylephrine drip: A prospective observational cohort study. J Matern Fetal Neonatal Med. 2018 May 22:1-141. doi: 10.1080/14767058.2018.1480604. [Epub ahead of print] PubMed PMID: 29788801. 3: Duran J, Troncoso MF, Lagos D, Ramos S, Marin G, Estrada M. GDF11 Modulates Ca(2+)-Dependent Smad2/3 Signaling to Prevent Cardiomyocyte Hypertrophy. Int J Mol Sci. 2018 May 18;19(5). pii: E1508. doi: 10.3390/ijms19051508. PubMed PMID: 29783655. 4: Palao T, van Weert A, de Leeuw A, de Vos J, Bakker ENTP, van Bavel E. Sustained conduction of vasomotor responses in rat mesenteric arteries in a two-compartment in vitro setup. Acta Physiol (Oxf). 2018 May 21:e13099. doi: 10.1111/apha.13099. [Epub ahead of print] PubMed PMID: 29783282. 5: Obata S, Miki A, Imai H, Nakamura M. Bilateral corneal denting after surgery under general anesthesia: A case report. Am J Ophthalmol Case Rep. 2018 Apr 19;10:290-292. doi: 10.1016/j.ajoc.2018.04.011. eCollection 2018 Jun. PubMed PMID: 29780956; PubMed Central PMCID: PMC5956712. 6: Aljunaidy MM, Morton JS, Kirschenman R, Phillips T, Case CP, Cooke CM, Davidge ST. Maternal Treatment with a Placental-Targeted Antioxidant (MitoQ) Impacts Offspring Cardiovascular Function in a Rat Model of Prenatal Hypoxia. Pharmacol Res. 2018 May 17. pii: S1043-6618(18)30102-6. doi: 10.1016/j.phrs.2018.05.006. [Epub ahead of print] PubMed PMID: 29778808. 7: Dong HW, Zhang LF, Bao SL. AMPK regulates energy metabolism through the SIRT1 signaling pathway to improve myocardial hypertrophy. Eur Rev Med Pharmacol Sci. 2018 May;22(9):2757-2766. doi: 10.26355/eurrev_201805_14973. PubMed PMID: 29771428. 8: Biazi GR, Frasson IG, Miksza DR, de Morais H, de Fatima Silva F, Bertolini GL, de Souza HM. Decreased hepatic response to glucagon, adrenergic agonists, and cAMP in glycogenolysis, gluconeogenesis, and glycolysis in tumor-bearing rats. J Cell Biochem. 2018 May 15. doi: 10.1002/jcb.27027. [Epub ahead of print] PubMed PMID: 29761924. 9: Mishra RC, Rahman MM, Davis MJ, Wulff H, Hill MA, Braun AP. Alpha(1) -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries. Physiol Rep. 2018 May;6(9):e13703. doi: 10.14814/phy2.13703. PubMed PMID: 29756401; PubMed Central PMCID: PMC5949301. 10: do Vale GT, Simplicio JA, Gonzaga NA, Yokota R, Ribeiro AA, Casarini DE, de Martinis BS, Tirapelli CR. Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol. Atherosclerosis. 2018 Apr 30;274:67-76. doi: 10.1016/j.atherosclerosis.2018.04.041. [Epub ahead of print] PubMed PMID: 29753230. 11: Khaddaj-Mallat R, Mathew John C, Braun AP. SKA-31, an activator of endothelial Ca(2+)-activated K(+) channels evokes robust vasodilation in rat mesenteric arteries. Eur J Pharmacol. 2018 May 9;831:60-67. doi: 10.1016/j.ejphar.2018.05.006. [Epub ahead of print] PubMed PMID: 29753043. 12: Hassan NA, Bassossy HME, Fahmy A, Mahmoud MF. Limonin alleviates macro- and micro-vascular complications of metabolic syndrome in rats: A comparative study with azelnidipine. Phytomedicine. 2018 Apr 1;43:92-102. doi: 10.1016/j.phymed.2018.03.044. Epub 2018 Mar 26. PubMed PMID: 29747759. 13: Ando M, Matsumoto T, Taguchi K, Kobayashi T. Decreased contraction induced by endothelium-derived contracting factor in prolonged treatment of rat renal artery with endoplasmic reticulum stress inducer. Naunyn Schmiedebergs Arch Pharmacol. 2018 May 4. doi: 10.1007/s00210-018-1508-2. [Epub ahead of print] PubMed PMID: 29728739. 14: Shaligram S, Sangüesa G, Akther F, Alegret M, Laguna JC, Rahimian R. Differential effects of high consumption of fructose or glucose on mesenteric arterial function in female rats. J Nutr Biochem. 2018 Apr 3;57:136-144. doi: 10.1016/j.jnutbio.2018.03.021. [Epub ahead of print] PubMed PMID: 29727795. 15: Bigonnesse E, Sicotte B, Brochu M. Activated NO pathway in uterine arteries during pregnancy in IUGR rat model. Am J Physiol Heart Circ Physiol. 2018 May 4. doi: 10.1152/ajpheart.00457.2017. [Epub ahead of print] PubMed PMID: 29727218. 16: Vasconcelos TB, Ribeiro-Filho HV, Lahlou S, Pereira JGC, Oliveira PSL, Magalhães PJC. Vasodilator effects and putative guanylyl cyclase stimulation by 2-nitro-1-phenylethanone and 2-nitro-2-phenyl-propane-1,3-diol on rat aorta. Eur J Pharmacol. 2018 Jul 5;830:105-114. doi: 10.1016/j.ejphar.2018.04.029. Epub 2018 Apr 28. PubMed PMID: 29709439. 17: Kruse NT, Hughes WE, Ueda K, Hanada S, Feider AJ, Iwamoto E, Bock JM, Casey DP. Impaired modulation of postjunctional α(1) -, but not α(2) -adrenergic vasoconstriction in contracting forearm muscle of postmenopausal women. J Physiol. 2018 Apr 30. doi: 10.1113/JP275777. [Epub ahead of print] PubMed PMID: 29708589. 18: Oliveira TF, Batista PR, Leal MA, Campagnaro BP, Nogueira BV, Vassallo DV, Meyrelles SS, Padilha AS. Chronic Cadmium Exposure Accelerates the Development of Atherosclerosis and Induces Vascular Dysfunction in the Aorta of ApoE(-/-) Mice. Biol Trace Elem Res. 2018 Apr 29. doi: 10.1007/s12011-018-1359-1. [Epub ahead of print] PubMed PMID: 29707746. 19: Xu M, Chen X, Huang Z, Chen D, Yu B, Chen H, He J, Zheng P, Luo J, Yu J, Luo Y. MicroRNA-139-5p suppresses myosin heavy chain I and IIa expression via inhibition of the calcineurin/NFAT signaling pathway. Biochem Biophys Res Commun. 2018 Jun 12;500(4):930-936. doi: 10.1016/j.bbrc.2018.04.202. Epub 2018 Apr 30. PubMed PMID: 29705696. 20: Roedel M, Ravens U, Kasper M, Wirth MP, Jepps TA, Propping S. Contractile responses in intact and mucosa-denuded human ureter-a comparison with urinary bladder detrusor preparations. Naunyn Schmiedebergs Arch Pharmacol. 2018 Apr 28. doi: 10.1007/s00210-018-1505-5. [Epub ahead of print] PubMed PMID: 29704028.