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MedKoo Cat#: 565492 | Name: MD-224 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MD-224 is a novel highly potent and efficacious mdm2 degrader

Chemical Structure

MD-224 HCl
MD-224 HCl
CAS#MD-224 HCl

Theoretical Analysis

MedKoo Cat#: 565492

Name: MD-224 HCl

CAS#: MD-224 HCl

Chemical Formula: C48H44Cl3FN6O6

Exact Mass: 0.0000

Molecular Weight: 926.26

Elemental Analysis: C, 62.24; H, 4.79; Cl, 11.48; F, 2.05; N, 9.07; O, 10.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2136247-12-4 (free base) MD-224 HCl
Synonym
MD-224 HCl; MD-224 hydrochloride, MD-224; MD 224; MD224
IUPAC/Chemical Name
(3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide hydrohloride
InChi Key
TZUDZUGDQFSPMC-JLJLNKMBSA-N
InChi Code
InChI=1S/C48H43Cl2FN6O6.ClH/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60;/h7-8,10-19,25,37,39,41,56H,1-2,4-6,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60);1H/t37?,39-,41+,48+;/m0./s1
SMILES Code
O=C(NC1=CC=C(C=C1)C(NCCCC#CC2=CC=CC3=C2CN(C3=O)C(C(N4)=O)CCC4=O)=O)[C@@H]5NC6(CCCCC6)[C@@]7(C(NC8=C7C=CC(Cl)=C8)=O)[C@H]5C9=CC=CC(Cl)=C9F.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 926.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Y, Yang J, Aguilar A, McEachern D, Przybranowski S, Liu L, Yang CY, Wang M, Han X, Wang S. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. doi: 10.1021/acs.jmedchem.8b00909. Epub 2018 Dec 10. PubMed PMID: 30525597; PubMed Central PMCID: PMC6545112.