AP14145| CAS#1446770-54-2| allosteric modulator| MedKoo

MedKoo Cat#: 565463 | Name: AP14145

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AP14145 is a allosteric sk channel modulator

Chemical Structure

AP14145

CAS#1446770-54-2 (free base)

Theoretical Analysis

MedKoo Cat#: 565463

Name: AP14145

CAS#: 1446770-54-2 (free base)

Chemical Formula: C18H17F3N4O

Exact Mass: 362.1354

Molecular Weight: 362.36

Elemental Analysis: C, 59.66; H, 4.73; F, 15.73; N, 15.46; O, 4.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1446770-54-2 (free base) 2387505-59-9 (HCl)

Synonym

AP14145; AP 14145; AP-14145

IUPAC/Chemical Name

(R)-N-(2-((1-(3-(Trifluoromethyl)phenyl)ethyl)amino)-1H-benzo[d]imidazol-4-yl)acetamide

InChi Key

NLXYWXWZVMFJQS-SNVBAGLBSA-N

InChi Code

InChI=1S/C18H17F3N4O/c1-10(12-5-3-6-13(9-12)18(19,20)21)22-17-24-15-8-4-7-14(16(15)25-17)23-11(2)26/h3-10H,1-2H3,(H,23,26)(H2,22,24,25)/t10-/m1/s1

SMILES Code

CC(NC1=C2C(NC(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)=N2)=CC=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 362.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kirchhoff JE, Skarsfeldt MA, Muthukumarasamy KM, Simó-Vicens R, Bomholtz SH, Abildgaard L, Jespersen T, Sørensen US, Grunnet M, Bentzen BH, Diness JG. The K(Ca)2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts. Front Pharmacol. 2019 Jun 19;10:668. doi: 10.3389/fphar.2019.00668. eCollection 2019. PubMed PMID: 31275147; PubMed Central PMCID: PMC6593233. 2: Diness JG, Skibsbye L, Simó-Vicens R, Santos JL, Lundegaard P, Citerni C, Sauter DRP, Bomholtz SH, Svendsen JH, Olesen SP, Sørensen US, Jespersen T, Grunnet M, Bentzen BH. Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca(2+)-Activated K(+) Channels in Pigs. Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005125. doi: 10.1161/CIRCEP.117.005125. PubMed PMID: 29018164; PubMed Central PMCID: PMC5647113. 3: Simó-Vicens R, Kirchhoff JE, Dolce B, Abildgaard L, Speerschneider T, Sørensen US, Grunnet M, Diness JG, Bentzen BH. A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K(Ca) 2) channels. Br J Pharmacol. 2017 Dec;174(23):4396-4408. doi: 10.1111/bph.14043. Epub 2017 Oct 22. PubMed PMID: 28925012; PubMed Central PMCID: PMC5715977.