GSK2798745 is a potent and selective TRPV4 Ion Channel Inhibitor with IC50 = 1.8 nM. GSK2798745 is potentially useful for the treatment of pulmonary edema associated with congestive heart failure. GSK2798745 demonstrated efficacy in an in vivo rat PK/PD model of pulmonary edema, excellent TRP selectivity (M5, A1, C3, and C6 > 25 μM), and an adequate preclinical safety profile that enabled its candidate selection and subsequent progression to clinical trials.
MedKoo Cat#: 555582
Name: GSK2798745
CAS#: 1419609-94-1
Chemical Formula: C25H28N6O3
Exact Mass: 460.2223
Molecular Weight: 460.54
Elemental Analysis: C, 65.20; H, 6.13; N, 18.25; O, 10.42
The following data is based on the product molecular weight 460.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
