MedKoo Cat#: 464093 | Name: Carbazomycin C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus, the fungi T. asteroides and T. mentagrophytes, and P. falciparum. It is also active against a panel of five plant pathogenic fungi. Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts.

Chemical Structure

Carbazomycin C
Carbazomycin C
CAS#108073-62-7

Theoretical Analysis

MedKoo Cat#: 464093

Name: Carbazomycin C

CAS#: 108073-62-7

Chemical Formula: C16H17NO3

Exact Mass: 271.1208

Molecular Weight: 271.32

Elemental Analysis: C, 70.83; H, 6.32; N, 5.16; O, 17.69

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Synonym
Carbazomycin C; Carbazomycin-C;
IUPAC/Chemical Name
3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-ol
InChi Key
MKNADQBPZINGKC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17NO3/c1-8-9(2)16(20-4)15(18)13-11-7-10(19-3)5-6-12(11)17-14(8)13/h5-7,17-18H,1-4H3
SMILES Code
OC1=C2C3=CC(OC)=CC=C3NC2=C(C(C)=C1OC)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 271.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Naid T, Kitahara T, Kaneda M, Nakamura S. Carbazomycins C, D, E and F, minor components of the carbazomycin complex. J Antibiot (Tokyo). 1987 Feb;40(2):157-64. doi: 10.7164/antibiotics.40.157. PMID: 3570964. 2: Hook DJ, Yacobucci JJ, O'Connor S, Lee M, Kerns E, Krishnan B, Matson J, Hesler G. Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J Antibiot (Tokyo). 1990 Oct;43(10):1347-8. doi: 10.7164/antibiotics.43.1347. PMID: 2258335.