CTX-0124143 | CAS#423731-64-0 | KAT6A inhibitor

MedKoo Cat#: 555577 | Name: CTX-0124143

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CTX-012414 is a KAT6A inhibitor with IC50 value of 0.49 μM and KD value of 0.38 M.

Chemical Structure

CTX-0124143

CAS#423731-64-0

Theoretical Analysis

MedKoo Cat#: 555577

Name: CTX-0124143

CAS#: 423731-64-0

Chemical Formula: C17H13FN2O3S

Exact Mass: 344.0631

Molecular Weight: 344.36

Elemental Analysis: C, 59.29; H, 3.81; F, 5.52; N, 8.14; O, 13.94; S, 9.31

Price and Availability

Size	Price	Availability
25mg	USD 250.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,450.00	2 Weeks
1g	USD 3,450.00	2 Weeks
2g	USD 5,950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

CTX-0124143; CTX 0124143; CTX0124143;

IUPAC/Chemical Name

N'-(2-fluorobenzoyl)naphthalene-2-sulfonohydrazide

InChi Key

CMGWGSMHPCWLOH-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H13FN2O3S/c18-16-8-4-3-7-15(16)17(21)19-20-24(22,23)14-10-9-12-5-1-2-6-13(12)11-14/h1-11,20H,(H,19,21)

SMILES Code

O=S(C1=CC=C2C=CC=CC2=C1)(NNC(C3=CC=CC=C3F)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 344.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Duan Y, Zhao Y, Li Z, Liu Z, Wang M, Wang X, Sun M, Song C, Yao Y. Discovery of N-(2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy. Eur J Med Chem. 2023 Nov 15;260:115770. doi: 10.1016/j.ejmech.2023.115770. Epub 2023 Aug 26. PMID: 37651878. 2: Su J, Wang X, Bai Y, Sun M, Yao Y, Duan Y. The role of MOZ/KAT6A in hematological malignancies and advances in MOZ/KAT6A inhibitors. Pharmacol Res. 2021 Dec;174:105930. doi: 10.1016/j.phrs.2021.105930. Epub 2021 Oct 6. PMID: 34626770. 3: Leaver DJ, Cleary B, Nguyen N, Priebbenow DL, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White KL, Katneni K, Cuellar M, Strasser JM, Dahlin JL, Walters MA, Street IP, Monahan BJ, Jarman KE, Sabroux HJ, Falk H, Chung MC, Hermans SJ, Parker MW, Thomas T, Baell JB. Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J Med Chem. 2019 Aug 8;62(15):7146-7159. doi: 10.1021/acs.jmedchem.9b00665. Epub 2019 Jul 17. PMID: 31256587. 4: Priebbenow DL, Leaver DJ, Nguyen N, Cleary B, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White KL, Shackleford DM, Katneni K, Cuellar M, Strasser JM, Dahlin JL, Walters MA, Street IP, Monahan BJ, Jarman KE, Jousset Sabroux H, Falk H, Chung MC, Hermans SJ, Downer NL, Parker MW, Voss AK, Thomas T, Baell JB. Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J Med Chem. 2020 May 14;63(9):4655-4684. doi: 10.1021/acs.jmedchem.9b02071. Epub 2020 Mar 19. PMID: 32118427. 5: Wang J, Yu Z, Hu Y, Li F, Huang X, Zhao X, Tang Y, Fang S, Tang Y. EGCG promotes the sensory function recovery in rats after dorsal root crush injury by upregulating KAT6A and inhibiting pyroptosis. Transl Neurosci. 2023 Dec 14;14(1):20220326. doi: 10.1515/tnsci-2022-0326. PMID: 38152093; PMCID: PMC10751571.