MedKoo Cat#: 573725 | Name: Allixin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Allixin is a phytoallexin found in garlic (Allium sativum) bulbs. Allixin has weak antimicrobial activity and exerts an anti-promoting activity against skin tumors induced by the chemical 12-O-tetradecanoylphorbol-13-acetate (TPA). Allixin also demonstrates an inhibitory effect on aflatoxin B1-induced mutagenesis.

Chemical Structure

Allixin
Allixin
CAS#125263-70-9

Theoretical Analysis

MedKoo Cat#: 573725

Name: Allixin

CAS#: 125263-70-9

Chemical Formula: C12H18O4

Exact Mass: 226.1205

Molecular Weight: 226.27

Elemental Analysis: C, 63.70; H, 8.02; O, 28.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Allixin
IUPAC/Chemical Name
3-Hydroxy-5-methoxy-6-methyl-2-pentyl-4H-pyran-4-one
InChi Key
OHRPDNHRQKOLGN-UHFFFAOYSA-N
InChi Code
1S/C12H18O4/c1-4-5-6-7-9-10(13)11(14)12(15-3)8(2)16-9/h13H,4-7H2,1-3H3
SMILES Code
CCCCCc1c(c(=O)c(c(o1)C)OC)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 226.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nakayama A, Hiromura M, Adachi Y, Sakurai H. Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism. J Biol Inorg Chem. 2008 Jun;13(5):675-84. doi: 10.1007/s00775-008-0352-0. Epub 2008 Feb 21. PubMed PMID: 18288506. 2: Kodera Y, Ichikawa M, Yoshida J, Kashimoto N, Uda N, Sumioka I, Ide N, Ono K. Pharmacokinetic study of allixin, a phytoalexin produced by garlic. Chem Pharm Bull (Tokyo). 2002 Mar;50(3):354-63. PubMed PMID: 11911198. 3: Mahady GB, Matsuura H, Pendland SL. Allixin, a phytoalexin from garlic, inhibits the growth of Helicobacter pylori in vitro. Am J Gastroenterol. 2001 Dec;96(12):3454-5. PubMed PMID: 11774979. 4: Moriguchi T, Matsuura H, Itakura Y, Katsuki H, Saito H, Nishiyama N. Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity. Life Sci. 1997;61(14):1413-20. PubMed PMID: 9335231. 5: Yamasaki T, Teel RW, Lau BH. Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1. Cancer Lett. 1991 Aug;59(2):89-94. PubMed PMID: 1909211.