MedKoo Cat#: 571682 | Name: Alkyne-ethyl-PEG1-t-Butyl ester
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alkyne-ethyl-PEG1-t-Butyl ester is a PEG derivative containing an alkyne group and a t-butyl protected carboxyl group. The alkyne can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Chemical Structure

Alkyne-ethyl-PEG1-t-Butyl ester
CAS#2100306-55-4

Theoretical Analysis

MedKoo Cat#: 571682

Name: Alkyne-ethyl-PEG1-t-Butyl ester

CAS#: 2100306-55-4

Chemical Formula: C11H18O3

Exact Mass: 198.1256

Molecular Weight: 198.26

Elemental Analysis: C, 66.64; H, 9.15; O, 24.21

Price and Availability

Size Price Availability Quantity
250mg USD 465.00 2 Weeks
500mg USD 850.00 2 Weeks
1g USD 1,350.00 2 Weeks
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Synonym
Alkyne-ethyl-PEG1-t-Butyl ester
IUPAC/Chemical Name
Alkyne-ethyl-PEG1-t-Butyl ester
InChi Key
NXVOMDPNTSWTMT-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H18O3/c1-5-6-8-13-9-7-10(12)14-11(2,3)4/h1H,6-9H2,2-4H3
SMILES Code
C#CCCOCCC(OC(C)(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The protected carboxyl group can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.

Preparing Stock Solutions

The following data is based on the product molecular weight 198.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. 2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417. 3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016. 4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129.