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MedKoo Cat#: 584991 | Name: Fominoben

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fominoben has antitussive and respiratory stimulant effects.

Chemical Structure

Fominoben
Fominoben
CAS#18053-31-1

Theoretical Analysis

MedKoo Cat#: 584991

Name: Fominoben

CAS#: 18053-31-1

Chemical Formula: C21H24ClN3O3

Exact Mass: 401.1506

Molecular Weight: 401.89

Elemental Analysis: C, 62.76; H, 6.02; Cl, 8.82; N, 10.46; O, 11.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fominoben; Fominobene; Fominobenum
IUPAC/Chemical Name
3'-Chloro-2'-(N-methyl-N-((morpholino-carbonyl)methyl)aminomethyl)benzanilide
InChi Key
KSNNEUZOAFRTDS-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24ClN3O3/c1-24(15-20(26)25-10-12-28-13-11-25)14-17-18(22)8-5-9-19(17)23-21(27)16-6-3-2-4-7-16/h2-9H,10-15H2,1H3,(H,23,27)
SMILES Code
O=C(NC1=CC=CC(Cl)=C1CN(C)CC(N2CCOCC2)=O)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baldino F Jr, Krespan B, Geller HM. Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors. Pharmacol Biochem Behav. 1984 Jul;21(1):137-43. PubMed PMID: 6087374. 2: Crawley JN, Blumstein LK, Baldino F Jr. Anxiolytic-like properties of fominoben. Eur J Pharmacol. 1984 Jan 27;97(3-4):277-81. PubMed PMID: 6142823. 3: Zimmer A, Krüger G, Prox A, Stahl E, Wolter B, Wachsmuth H, Köster P. [Studies on the biotransformation of fominoben-HCl in man (author's transl)]. Arzneimittelforschung. 1978;28(4):688-92. German. PubMed PMID: 155457. 4: Völpel S, Lichtenauer I, Eichler J. [On the respiration analeptic effect of fominoben HCl after administration of pethidine/promethazine (author's transl)]. Arzneimittelforschung. 1979;29(2):334-6. German. PubMed PMID: 36111. 5: Sasaki T, Sugiyama M, Sasaki H, Suzuki S, Takishima T. Effects of the antitussive fominoben (PB89) on hypoxia in chronic obstructive lung disease: comparison with dextromethorphan using a double-blind method. J Int Med Res. 1985;13(2):96-101. PubMed PMID: 3158563. 6: Nakanishi S, Shiohara E, Tsukada M, Kawahara I, Matsumura R, Nagakura A, Kohei H. Effects of fominoben-HCl on rat liver. Arzneimittelforschung. 1980;30(11):1884-7. PubMed PMID: 6450596. 7: Zimmer A. [Pharmacokinetics of fominoben-HCl in the dog and the rabbit (author's transl)]. Arzneimittelforschung. 1979;29(2):323-8. German. PubMed PMID: 156029. 8: Mulac K, Schmid P, Muhar F, Lochs P, Schlick W. [Effect of fominoben on ventilation, oxygen uptake and blood gases in patients with obstructive ventilation disorders]. Int J Clin Pharmacol Biopharm. 1976 Sep;14(2):93-100. German. PubMed PMID: 12114. 9: Schneiderhan H. [Symptomatic therapy of sarcoidosis using fominoben]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:353-5. German. PubMed PMID: 4740113. 10: Nolte D, Streller SE. [Fominoben and central respiratory control]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:348-5. German. PubMed PMID: 4740111. 11: Grabow L. [Respiratory function tests using fominoben]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:357-9. German. PubMed PMID: 4740115. 12: Schindl R. [Fominoben and respiratory function]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:342-7. German. PubMed PMID: 4740110. 13: Zimmer A. [Excretion and metabolic pattern of fominoben in the urine and feces of man rabbit, dog, and rat]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:317-9. German. PubMed PMID: 4740108. 14: Wieser O, Witzel K. [Fominoben, a new respiratory drug]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:337-8. German. PubMed PMID: 4740109. 15: Ammen K, Renovanz HD. [Determination of the interpleural pressure during fominoben therapy]. MMW Munch Med Wochenschr. 1978 Feb 24;120(8):253-4. German. PubMed PMID: 147416. 16: Gong MC. [Preliminary observations of the effect of fominoben on the ventilation, arterial oxygen pressure and arterial pH in the rabbit under hypoxia (author's transl)]. Zhonghua Jie He He Hu Xi Xi Ji Bing Za Zhi. 1981 Mar;4(3):151-2. Chinese. PubMed PMID: 6459221. 17: Simon H, Felix R, Pensky W. [Ventilation and pulmonary perfusion in chronic obstructive airways disease under Fominoben author's transl]. Med Klin. 1975 Jun 13;70(24):1043-7. German. PubMed PMID: 125378. 18: Gerhard K. [Long-term therapy with the respiratory agent fominoben]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:361-3. German. PubMed PMID: 4740117. 19: Huber G. [Determination of the optimum effective dosage of the respiratory agent fominoben]. Arzneimittelforschung. 1973 Feb;23:Suppl 2a:359-6. German. PubMed PMID: 4740116. 20: Danielczyk W. [The effect of fominoben on the EEG of Parkinson patients (author's transl)]. MMW Munch Med Wochenschr. 1976 Aug 20;118(34):1057-8. German. PubMed PMID: 134282.