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MedKoo Cat#: 598258 | Name: Amoxicillin sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amoxicillin sodium is a broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.

Chemical Structure

Amoxicillin sodium
Amoxicillin sodium
CAS#34642-77-8 (sodium)

Theoretical Analysis

MedKoo Cat#: 598258

Name: Amoxicillin sodium

CAS#: 34642-77-8 (sodium)

Chemical Formula: C16H18N3NaO5S

Exact Mass: 0.0000

Molecular Weight: 387.38

Elemental Analysis: C, 49.61; H, 4.68; N, 10.85; Na, 5.93; O, 20.65; S, 8.28

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
25g USD 950.00 2 Weeks
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Related CAS #
26787-78-0 (anhydrous) 34642-77-8 (sodium) 61336-70-7 (hydrate) 119229-00-4 (embonate) 73590-06-4 (dimer) 26889-93-0 (L-Amoxicillin)
Synonym
Amoxicillin sodium; Lamoxy; Penamox; BRL-2333AB-B; Moxacin;
IUPAC/Chemical Name
sodium (2S,5R,6R)-6-(2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
InChi Key
BYHDFCISJXIVBV-GJUCOGTPSA-M
InChi Code
InChI=1S/C16H19N3O5S.Na/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);/q;+1/p-1/t9?,10-,11+,14-;/m1./s1
SMILES Code
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C(N)C3=CC=C(O)C=C3)=O)N1C2=O)[O-].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 387.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Development and validation of HPLC-DAD method for the simultaneous determination of amoxicillin, metronidazole and rabeprazole sodium. Application to spiked simulated intestinal fluid samples. Ann Pharm Fr. 2015 Sep;73(5):351-60. doi: 10.1016/j.pharma.2015.04.008. Epub 2015 May 27. PubMed PMID: 26024556. 5: Mori F, Barni S, Pucci N, Rossi ME, de Martino M, Novembre E. Cutaneous adverse reactions to amoxicillin-clavulanic acid suspension in children: the role of sodium benzoate. Curr Drug Saf. 2012 Apr;7(2):87-91. PubMed PMID: 22873492. 6: Wang Y, Wang B, Lv ZF, Yang Y, Wang F, Wang H, Chen S, Xie Y, Zhou X. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81. doi: 10.1111/hel.12136. Epub 2014 May 14. Review. PubMed PMID: 24826809. 7: Gottberg B, Berné J, Quiñónez B, Solórzano E. Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats. Med Oral Patol Oral Cir Bucal. 2014 Jan 1;19(1):e38-43. PubMed PMID: 24121904; PubMed Central PMCID: PMC3909430. 8: Furuta T, Kato M, Sugimoto M, Sasaki M, Kamoshida T, Furukawa K, Inaba T, Tomita T, Shirai T, Ishii N, Nomura H, Konda Y, Asaka M; Japan Gast Study Group. Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H. pylori infection. Intern Med. 2011;50(5):369-74. Epub 2011 Mar 1. PubMed PMID: 21372444. 9: Kuroki H, Ishiwada N, Inoue N, Ishikawa N, Suzuki H, Himi K, Kurosaki T. Comparison of clinical efficacy between 3-day combined clavulanate/amoxicillin preparation treatment and 10-day amoxicillin treatment in children with pharyngolaryngitis or tonsillitis. J Infect Chemother. 2013 Feb;19(1):12-9. doi: 10.1007/s10156-012-0444-1. Epub 2012 Jul 4. PubMed PMID: 22760341. 10: Wu Z, Hou J, Wang Y, Chai M, Xiong Y, Lu W, Pan J. Preparation and evaluation of amoxicillin loaded dual molecularly imprinted nanoparticles for anti-Helicobacter pylori therapy. Int J Pharm. 2015 Dec 30;496(2):1006-14. doi: 10.1016/j.ijpharm.2015.10.065. Epub 2015 Oct 30. PubMed PMID: 26524712. 11: Hentzien M, Lambert D, Limelette A, N'Guyen Y, Robbins A, Lebrun D, Jaussaud R, Bani-Sadr F. Macroscopic amoxicillin crystalluria. Lancet. 2015 Jun 6;385(9984):2296. doi: 10.1016/S0140-6736(14)62001-8. Epub 2015 Feb 11. PubMed PMID: 25680270. 12: Arnež M, Ružić-Sabljić E. Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans. Pediatr Infect Dis J. 2015 Oct;34(10):1045-8. doi: 10.1097/INF.0000000000000804. PubMed PMID: 26186104. 13: Lim JW, Jung MH, Jung SJ, Kim DH, Park KH, Kang SY. The efficacy of amoxicillin sodium against streptococcosis in cultured olive flounder Paralichthys olivaceus and its pharmacokinetics. J Vet Pharmacol Ther. 2017 Jan;40(1):77-87. doi: 10.1111/jvp.12321. Epub 2016 May 26. PubMed PMID: 27226029. 14: Angadi SC, Manjeshwar LS, Aminabhavi TM. Novel composite blend microbeads of sodium alginate coated with chitosan for controlled release of amoxicillin. Int J Biol Macromol. 2012 Jul-Aug;51(1-2):45-55. doi: 10.1016/j.ijbiomac.2012.04.018. Epub 2012 Apr 24. PubMed PMID: 22560962. 15: Franco GC, Baglie S, Ruenis AP, Franco LM, Cogo K, Oshima-Franco Y, Silva P, Groppo FC, Rosalen PL. Bioequivalence study of two commercial amoxicillin suspension formulations in healthy human volunteers. Int J Clin Pharmacol Ther. 2014 May;52(5):425-30. doi: 10.5414/CP202039. PubMed PMID: 24755132. 16: Szultka M, Krzeminski R, Walczak J, Jackowski M, Buszewski B. Pharmacokinetic study of amoxicillin in human plasma by solid-phase microextraction followed by high-performance liquid chromatography-triple quadrupole mass spectrometry. Biomed Chromatogr. 2014 Feb;28(2):255-64. doi: 10.1002/bmc.3014. Epub 2013 Sep 5. PubMed PMID: 24006329. 17: Liew KB, Loh GO, Tan YT, Peh KK. Randomized two-way cross-over bioequivalence study of two amoxicillin formulations and inter-ethnicity pharmacokinetic variation in healthy Malay volunteers. Biomed Chromatogr. 2014 Sep;28(9):1246-53. doi: 10.1002/bmc.3153. Epub 2014 Mar 3. PubMed PMID: 24585432. 18: Vahdat L, Sunderland B. The influence of potassium clavulanate on the rate of amoxicillin sodium degradation in phosphate and acetate buffers in the liquid state. Drug Dev Ind Pharm. 2009 Apr;35(4):471-9. doi: 10.1080/03639040802438373 . PubMed PMID: 19048426. 19: Naguib IA, Abdelaleem EA, Zaazaa HE, Hussein EA. Partial Least-Squares and Linear Support Vector Regression Chemometric Methods for Simultaneous Determination of Amoxicillin Trihydrate and Dicloxacillin Sodium in the Presence of Their Common Impurity. J AOAC Int. 2016 Jul;99(4):972-979. doi: 10.5740/jaoacint.16-0033. Epub 2016 Jun 15. PubMed PMID: 27305461. 20: Lin ZW, Li Y, Song WJ, Hu HY, Zeng Y, Xu BH. [Simultaneous determination of serum concentrations of amoxicillin and clavulanate potassium in human blood using high-performance liquid chromatography]. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(6):1069-71. Chinese. PubMed PMID: 21690072.

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AZD-6605

AZD-6605