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MedKoo Cat#: 555558 | Name: PhTX-433 TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PhTX-433, also known as Philanthotoxin 433, is a polyamine-containing toxin, which blocks NMDA-gated ion channels; originally isolated from the venom of the wasp Philanthus triangulum.

Chemical Structure

PhTX-433 TFA
PhTX-433 TFA
CAS#276684-27-6 (TFA)

Theoretical Analysis

MedKoo Cat#: 555558

Name: PhTX-433 TFA

CAS#: 276684-27-6 (TFA)

Chemical Formula: C29H44F9N5O9

Exact Mass: 0.0000

Molecular Weight: 777.68

Elemental Analysis: C, 44.79; H, 5.70; F, 21.99; N, 9.01; O, 18.52

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Related CAS #
276684-27-6 (TFA) 115976-91-5 (free base)
Synonym
PhTX-433; PhTX 433; PhTX433; Philanthotoxin 433; Philanthotoxin-433; Philanthotoxin433;
IUPAC/Chemical Name
(S)-N-(1-((4-((3-((3-aminopropyl)amino)propyl)amino)butyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide tris(2,2,2-trifluoroacetate)
InChi Key
UROZAUWUTBOQNV-YDULTXHLSA-N
InChi Code
InChI=1S/C23H41N5O3.3C2HF3O2/c1-2-7-22(30)28-21(18-19-8-10-20(29)11-9-19)23(31)27-17-4-3-13-25-15-6-16-26-14-5-12-24;3*3-2(4,5)1(6)7/h8-11,21,25-26,29H,2-7,12-18,24H2,1H3,(H,27,31)(H,28,30);3*(H,6,7)/t21-;;;/m0.../s1
SMILES Code
CCCC(N[C@@H](CC1=CC=C(O)C=C1)C(NCCCCNCCCNCCCN)=O)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Philanthotoxins are components of the venom of the Egyptian solitary wasp Philanthus triangulum, commonly known as the European beewolf. Philanthotoxins are polyamine toxins, a group of toxins isolated from the venom of wasps and spiders which immediately but reversibly paralyze their prey.[δ-philanthotoxin, also known as PhTX-433, is the most active philanthotoxin that can be refined from the venom.PhTX-433 functions by blocking excitatory neurotransmitter ion channels, including nicotinic acetylcholine receptors (NAChRs) and ionotropic glutamate receptors (iGluRs). While the IC50 values of philanthotoxins varies between analogues and receptor subunit composition, the IC50 value of PhTX-433 at the iGluR AMPA receptor naturally expressed in locust leg muscle is 18 μM and the IC50 value at rat nAChRs is 1 μM. (from https://en.wikipedia.org/wiki/Philanthotoxin)
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PhTX-433, also known as Philanthotoxin 433, is a polyamine-containing toxin, which blocks NMDA-gated ion channels.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 777.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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