Paeoniflorin | CAS#23180-57-6 | NMDA & TRPV1 receptor modulator

MedKoo Cat#: 584982 | Name: Peoniflorin

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Paeoniflorin is a monoterpene glycoside first isolated from the roots of peony. It has diverse cellular actions, including modulating NMDA and TRPV1 receptors.

Chemical Structure

Peoniflorin

CAS#23180-57-6

Theoretical Analysis

MedKoo Cat#: 584982

Name: Peoniflorin

CAS#: 23180-57-6

Chemical Formula: C23H28O11

Exact Mass: 480.1632

Molecular Weight: 480.47

Elemental Analysis: C, 57.50; H, 5.87; O, 36.63

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 240.00
100mg	USD 390.00
250mg	USD 670.00

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Paeoniflorin

IUPAC/Chemical Name

beta-D-Glucopyranoside, 5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta(cd)pentalen-1a(2H)-yl, (1aR-(1a-alpha,2-beta,3a-alpha,5-alpha,5a-alpha,5b-alpha))

InChi Key

YKRGDOXKVOZESV-GRPQXGFZSA-N

InChi Code

InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13?,14+,15+,16-,18+,19?,20?,21?,22?,23-/m0/s1

SMILES Code

O[C@@H]([C@@H]([C@@H]([C@H](CO)O1)O)O)[C@H]1O[C@@]2(C3)C(C4)(C)OC5OC4(O)C3C25COC(C6=CC=CC=C6)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Paeoniflorin is a heat shock protein-inducing compound.

In vitro activity:

PF (peoniflorin) significantly increased the percent cell viability of HUVECs injured by H(2)O(2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. By flow cytometric analysis, PF markedly attenuated H(2)O(2)-induced apoptosis and intracellular reactive oxygen species production. In addition, PF also displayed a dose-dependent reduction of lactate dehydrogenase leakage, malondialdehyde formation, and caspase-3 proteolytic activities in H(2)O(2)-treated cells, which was accompanied with a restoration of the activities of endogenous antioxidants, including total superoxide dismutase and glutathione peroxidase. Reference: Can J Physiol Pharmacol. 2011 Jun;89(6):445-53. https://pubmed.ncbi.nlm.nih.gov/21777057/

In vivo activity:

In CIA rats, the levels of anti-CII antibody, IgA, IgG and IgM in serum enhanced, BAFF, BAFF-R, PI3K, p-Akt and mTOR were highly expressed. Paeoniflorin (100mg/kg) obviously decreased arthritis score, relieved ankle and paw swelling, improved spleen histopathology in CIA rats, decreased the levels of IgA, IgM, IgG and anti-CII antibody, and significantly decreased the expressions of BAFF, BAFF-R, PI3K, p-Akt and mTOR. Reference: J Ethnopharmacol. 2012 May 7;141(1):290-300. https://pubmed.ncbi.nlm.nih.gov/22391142/

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	62.44
	DMSO	75.3	156.79
	Ethanol	63.0	131.12
	PBS (pH 7.2)	10.0	20.81
	Water	98.0	203.97

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 480.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Shen J, Yang F, Wang G, Mou X, Li J, Ding X, Wang X, Li H. Paeoniflorin alleviates inflammation in bovine mammary epithelial cells induced by Staphylococcus haemolyticus through TLR2/NF-κB signaling pathways. Res Vet Sci. 2023 Mar;156:95-103. doi: 10.1016/j.rvsc.2023.01.022. Epub 2023 Feb 10. PMID: 36796241. 2. Chen T, Guo ZP, Jiao XY, Zhang YH, Li JY, Liu HJ. Protective effects of peoniflorin against hydrogen peroxide-induced oxidative stress in human umbilical vein endothelial cells. Can J Physiol Pharmacol. 2011 Jun;89(6):445-53. doi: 10.1139/y11-034. Epub 2011 Jul 21. PMID: 21777057. 3. Ma H, Hao J, Liu H, Yin J, Qiang M, Liu M, He S, Zeng D, Liu X, Lian C, Gao Y. Peoniflorin Preconditioning Protects Against Myocardial Ischemia/Reperfusion Injury Through Inhibiting Myocardial Apoptosis: RISK Pathway Involved. Appl Biochem Biotechnol. 2022 Mar;194(3):1149-1165. doi: 10.1007/s12010-021-03680-z. Epub 2021 Oct 1. PMID: 34596828. 4. Li PP, Liu DD, Liu YJ, Song SS, Wang QT, Chang Y, Wu YJ, Chen JY, Zhao WD, Zhang LL, Wei W. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012 May 7;141(1):290-300. doi: 10.1016/j.jep.2012.02.034. Epub 2012 Feb 27. PMID: 22391142.

In vitro protocol:

In vivo protocol:

1. Ma H, Hao J, Liu H, Yin J, Qiang M, Liu M, He S, Zeng D, Liu X, Lian C, Gao Y. Peoniflorin Preconditioning Protects Against Myocardial Ischemia/Reperfusion Injury Through Inhibiting Myocardial Apoptosis: RISK Pathway Involved. Appl Biochem Biotechnol. 2022 Mar;194(3):1149-1165. doi: 10.1007/s12010-021-03680-z. Epub 2021 Oct 1. PMID: 34596828. 2. Li PP, Liu DD, Liu YJ, Song SS, Wang QT, Chang Y, Wu YJ, Chen JY, Zhao WD, Zhang LL, Wei W. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012 May 7;141(1):290-300. doi: 10.1016/j.jep.2012.02.034. Epub 2012 Feb 27. PMID: 22391142.

1: Xi H, Wang Z, Li M, Duan X, Li Y. Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress. Int J Mol Sci. 2024 Jul 30;25(15):8355. doi: 10.3390/ijms25158355. PMID: 39125927; PMCID: PMC11313479. 2: Luo Y, Wu W, Gao R, Guo Y. Optimized isolation and purification of Shaoyao Gancao decoction using macroporous resin. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Aug 15;1244:124251. doi: 10.1016/j.jchromb.2024.124251. Epub 2024 Jul 23. PMID: 39068869. 3: Han D, Jiang C, Xu H, Chu R, Zhang R, Fang R, Ge H, Lu M, Wang M, Tai Y, Yan S, Wei W, Wang Q. Inhibition of GRK2 ameliorates the pristane-induced mouse SLE model by suppressing plasma cells differentiation. Int Immunopharmacol. 2024 Sep 10;138:112557. doi: 10.1016/j.intimp.2024.112557. Epub 2024 Jun 26. PMID: 38936060. 4: Su L, Guo P, Guo X, He Z, Zhao Y, Zong Y, Li J, Chen W, DU R. Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy. Chin J Nat Med. 2024 Jun;22(6):515-529. doi: 10.1016/S1875-5364(24)60654-0. PMID: 38906599. 5: Yuan JP, Zhu PY, Sun YZ, Lu YS, Qi RQ, Chen HD, Wu Y. Paeoniflorin regulates RhoA/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in oxidative stressed melanocytes. Arch Dermatol Res. 2024 Jun 15;316(7):401. doi: 10.1007/s00403-024-03154-2. PMID: 38878083. 6: Wu Q, Que W, Zhang J, Chen X, Wang M, Kou J, Chen G. Enhanced effect of limb remote ischemic postconditioning combined with paeoniflorin on alleviating cerebral ischemic injury via neutrophil NADPH pathway. Brain Res Bull. 2024 Aug;214:111006. doi: 10.1016/j.brainresbull.2024.111006. Epub 2024 Jun 7. PMID: 38852654. 7: Chen J, He Q, Jin J. Targeting dendritic cell activation: the therapeutic impact of paeoniflorin in cortosteroid-dependent dermatitis management. Arch Dermatol Res. 2024 Jun 7;316(7):348. doi: 10.1007/s00403-024-03002-3. PMID: 38849562. 8: Shen S, Fu B, Deng L, Zhu G, Shi H, Tian G, Han C, Yi P, Peng L. Paeoniflorin protects chicken against APEC-induced acute lung injury by affecting the endocannabinoid system and inhibiting the PI3K/AKT and NF-κB signaling pathways. Poult Sci. 2024 Jul;103(7):103866. doi: 10.1016/j.psj.2024.103866. Epub 2024 May 16. PMID: 38833957; PMCID: PMC11179074. 9: Lu Y, Yin L, Yang W, Wu Z, Niu J. Antioxidant effects of Paeoniflorin and relevant molecular mechanisms as related to a variety of diseases: A review. Biomed Pharmacother. 2024 Jul;176:116772. doi: 10.1016/j.biopha.2024.116772. Epub 2024 May 28. PMID: 38810407. 10: Hu Y, Ge K, Du Y. Paeoniflorin alleviates TGF-β2-mediated extracellular matrix remodeling and oxidative stress in human trabecular meshwork cells. Int Ophthalmol. 2024 May 25;44(1):229. doi: 10.1007/s10792-024-02917-0. PMID: 38795168. 11: Su Y, Shen L, Zhu P, Liang X. UPLC-ESI-Q-TOF-MS/MS based metabolomics investigation on chemical constituent consistency of Zhenwu Decoction before and after compatibility. J Pharm Biomed Anal. 2024 Aug 15;246:116222. doi: 10.1016/j.jpba.2024.116222. Epub 2024 May 18. PMID: 38763106. 12: Wang JJ, Hao CF, Huang PY, Qin XL, Zhou SS, Xu JD, Mao Q, Li SL, Kong M. Integrating UPLC-QTOF-MS/MS and UPLC-DAD to evaluate the influence of sulfur- fumigated Paeoniae Radix Alba on the overall quality of three Si-Wu-Tang formulations. Phytochem Anal. 2024 Aug;35(6):1486-1495. doi: 10.1002/pca.3379. Epub 2024 May 13. PMID: 38740517. 13: Zhou W, Zuo H, Qian Y, Miao W, Chen C. Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of the Nrf2 signaling pathway. Chem Biol Interact. 2024 May 25;395:111032. doi: 10.1016/j.cbi.2024.111032. Epub 2024 May 4. PMID: 38705442. 14: Xu H, Zhang T, Li L, Qu Y, Li L, Yan Y, Wu L, Yan C. Paeoniflorin exerts anti-PTSD effects in adult rats by modulating hippocampus and amygdala histone acetylation modifications in response to early life stress. Chem Biol Interact. 2024 Jun 1;396:111035. doi: 10.1016/j.cbi.2024.111035. Epub 2024 May 3. PMID: 38703807. 15: Xu C, Wang X, Han J, Gu Z, Guo Q. LMD and LC-MS-based chemical constituents and pharmacological effects assessment for two different processing methods of the root of Paeonia lactiflora Pall. J Pharm Biomed Anal. 2024 Aug 1;245:116184. doi: 10.1016/j.jpba.2024.116184. Epub 2024 Apr 27. PMID: 38692214. 16: Li T, Mao N, Xie Z, Wang J, Jin F, Li Y, Liu S, Cai W, Gao X, Wei Z, Yang F, Xu H, Liu H, Zhang H, Xu D. Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models. Phytomedicine. 2024 Jul;129:155616. doi: 10.1016/j.phymed.2024.155616. Epub 2024 Apr 19. PMID: 38669965. 17: Wang QY, Liu SY, Yu DH, Chen PP, Wang Y, Lu F, Liu SM. Evaluation of drug interactions of Saposhnikoviae Radix and its major components with astragaloside IV and paeoniflorin using in vitro and in vivo experiments. J Chromatogr A. 2024 May 24;1723:464716. doi: 10.1016/j.chroma.2024.464716. Epub 2024 Feb 3. PMID: 38640881. 18: Deng Y, Zhao Q, Zhou HY, Zhang ZQ, Zhan Y. Activation of ASIC3/ERK pathway by paeoniflorin improves intestinal fluid metabolism and visceral sensitivity in slow transit constipated rats. Kaohsiung J Med Sci. 2024 Jun;40(6):561-574. doi: 10.1002/kjm2.12829. Epub 2024 Apr 17. PMID: 38634140. 19: Xu J, Lu L, Jiang S, Qin Z, Huang J, Huang M, Jin J. Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota. Eur J Pharmacol. 2024 May 15;971:176516. doi: 10.1016/j.ejphar.2024.176516. Epub 2024 Mar 19. PMID: 38513881. 20: Liu Y, Chen HY, Mi J, Wang FF, Wan GY, Cui C. [Inhibitory effect of paeoniflorin on CAL27 cells of tongue squamous cell carcinoma and its mechanism]. Shanghai Kou Qiang Yi Xue. 2023 Dec;32(6):597-602. Chinese. PMID: 38494967.