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MedKoo Cat#: 573683 | Name: Alnespirone hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alnespirone hydrochloride is a selective 5-HT1A receptor full agonist of the azapirone chemical class. It has both antidepressant and anxiolytic effects.

Chemical Structure

Alnespirone hydrochloride
Alnespirone hydrochloride
CAS#143413-68-7

Theoretical Analysis

MedKoo Cat#: 573683

Name: Alnespirone hydrochloride

CAS#: 143413-68-7

Chemical Formula: C26H39ClN2O4

Exact Mass: 478.2598

Molecular Weight: 479.06

Elemental Analysis: C, 65.19; H, 8.21; Cl, 7.40; N, 5.85; O, 13.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
138298-79-0 (free base)
Synonym
Alnespirone hydrochloride,Alnespirone HCl
IUPAC/Chemical Name
8-(4-((5-methoxychroman-3-yl)(propyl)amino)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride
InChi Key
QYFHCFNBYQZGKW-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H38N2O4.ClH/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26;/h8-10,20H,3-7,11-19H2,1-2H3;1H
SMILES Code
O=C(N(CCCCN(C1COC2=C(C(OC)=CC=C2)C1)CCC)C(C3)=O)CC43CCCC4.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 479.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cervo L, Munoz C, Bertaglia A, Samanin R. Alnespirone and buspirone have anxiolytic-like effects in a conflict procedure in rats by stimulating 5-HT(1A) receptors. Behav Pharmacol. 2000 Apr;11(2):153-60. PubMed PMID: 10877120. 2: Muñoz C, Papp M. Alnespirone (S 20499), an agonist of 5-HT1A receptors, and imipramine have similar activity in a chronic mild stress model of depression. Pharmacol Biochem Behav. 1999 Aug;63(4):647-53. PubMed PMID: 10462194. 3: Mac Sweeney CP, Lesourd M, Gandon JM. Antidepressant-like effects of alnespirone (S 20499) in the learned helplessness test in rats. Eur J Pharmacol. 1998 Mar 19;345(2):133-7. PubMed PMID: 9600628.