MedKoo Cat#: 565377 | Name: RNF5 inhibitor Inh-2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RNF5 inhibitor Inh-2 is a modulator of RNF5 downstream pathways which rescues F508del-CFTR activity on human primary bronchial epithelia, thereby decreasing ubiquitylation and increasing half-life of F508del-CFTR.

Chemical Structure

RNF5 inhibitor Inh-2
RNF5 inhibitor Inh-2
CAS#324579-65-9

Theoretical Analysis

MedKoo Cat#: 565377

Name: RNF5 inhibitor Inh-2

CAS#: 324579-65-9

Chemical Formula: C23H20N4S

Exact Mass: 384.1409

Molecular Weight: 384.50

Elemental Analysis: C, 71.85; H, 5.24; N, 14.57; S, 8.34

Price and Availability

Size Price Availability Quantity
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
1g USD 4,450.00 2 Weeks
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Synonym
RNF5 IN-2; RNF5-IN 2; RNF5-IN-2; RNF5 inhibitor Inh-2; RNF5 inhibitor Inh2
IUPAC/Chemical Name
(E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide
InChi Key
FYZFQLYZABRFAZ-KUXGFVDGSA-N
InChi Code
InChI=1S/C23H20N4S/c1-18-26-28-23(27(18)17-19-11-5-2-6-12-19)25-22(20-13-7-3-8-14-20)24-21-15-9-4-10-16-21/h2-16H,17H2,1H3/b24-22+,25-23-
SMILES Code
CC1=NS/C(N1CC2=CC=CC=C2)=N\C(C3=CC=CC=C3)=N\C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 384.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Brusa I, Sondo E, Pesce E, Tomati V, Gioia D, Falchi F, Balboni B, Ortega Martínez JA, Veronesi M, Romeo E, Margaroli N, Recanatini M, Girotto S, Pedemonte N, Roberti M, Cavalli A. Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5. J Med Chem. 2023 Jul 27;66(14):9797-9822. doi: 10.1021/acs.jmedchem.3c00608. Epub 2023 Jul 13. PMID: 37440686; PMCID: PMC10388311.