MedKoo Cat#: 565364 | Name: ASP2905 free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP2905 hydrochloride is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3).

Chemical Structure

ASP2905 free base
ASP2905 free base
CAS#792184-90-8 (free base)

Theoretical Analysis

MedKoo Cat#: 565364

Name: ASP2905 free base

CAS#: 792184-90-8 (free base)

Chemical Formula: C20H17FN8

Exact Mass: 388.1560

Molecular Weight: 388.41

Elemental Analysis: C, 61.85; H, 4.41; F, 4.89; N, 28.85

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
578016-50-9 (HCl) 792184-90-8 (free base) 1246834-45-6 (difumarate) 1246958-43-9 (fumarate)
Synonym
ASP2905; ASP-2905; ASP 2905; ASP2905 free base
IUPAC/Chemical Name
1,3,5-Triazine-2,4,6-triamine N2-(4-fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-
InChi Key
APYUZVKHUKMAIJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H17FN8/c21-14-7-9-16(10-8-14)26-20-28-18(24-13-17-22-11-4-12-23-17)27-19(29-20)25-15-5-2-1-3-6-15/h1-12H,13H2,(H3,24,25,26,27,28,29)
SMILES Code
FC1=CC=C(NC2=NC(NC3=CC=CC=C3)=NC(NCC4=NC=CC=N4)=N2)C=C1
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 388.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takahashi S, Ohmiya M, Honda S, Ni K. The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit/hyperactivity disorder. PLoS One. 2018 Nov 21;13(11):e0207750. doi: 10.1371/journal.pone.0207750. eCollection 2018. PubMed PMID: 30462746; PubMed Central PMCID: PMC6248980. 2: Takahashi S, Inamura K, Yarimizu J, Yamazaki M, Murai N, Ni K. Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3. Eur J Pharmacol. 2017 Sep 5;810:26-35. doi: 10.1016/j.ejphar.2017.05.045. Epub 2017 May 25. PubMed PMID: 28552344.