Murizatoclax, also known as AMG-397, is a potent and selective MCL-1 inhibitor. AMG 397 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
MedKoo Cat#: 207100
Name: Murizatoclax
CAS#: 2245848-05-7
Chemical Formula: C42H57ClN4O5S
Exact Mass: 764.3738
Molecular Weight: 765.45
Elemental Analysis: C, 65.90; H, 7.51; Cl, 4.63; N, 7.32; O, 10.45; S, 4.19
The following data is based on the product molecular weight 765.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |