Ortho-AP1867 is an isomer of AP1867. In Ortho-AP1867, the carboxymethoxy group is in ortho-position. AP1867, also known as dTAG acid, is a precursor for the dTAG system which pairs a novel degrader of FKBP12(F36V) with expression of FKBP12(F36V) in-frame with a protein of interest. It shows superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation. AP1867 characterizes immediate effects of KRAS(G12V) loss on proteomic signaling, and demonstrates rapid degradation in vivo.
MedKoo Cat#: 565348
Name: Ortho-AP1867
CAS#: 2230613-03-1
Chemical Formula: C38H47NO11
Exact Mass: 693.3149
Molecular Weight: 693.79
Elemental Analysis: C, 65.79; H, 6.83; N, 2.02; O, 25.37
The following data is based on the product molecular weight 693.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
