Tripiperaquine | CAS#53658-96-1 | anti-MDR

MedKoo Cat#: 584652 | Name: Tripiperaquine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tripiperaquine has been studied for reversing multi-drug resistance (MDR) in leukemia.

Chemical Structure

Tripiperaquine

CAS#53658-96-1

Theoretical Analysis

MedKoo Cat#: 584652

Name: Tripiperaquine

CAS#: 53658-96-1

Chemical Formula: C34H42Cl2N8

Exact Mass: 632.2909

Molecular Weight: 633.67

Elemental Analysis: C, 64.45; H, 6.68; Cl, 11.19; N, 17.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Tripiperaquine; M 1020

IUPAC/Chemical Name

4,4'-(1,4-Piperazinediylbis(2,1-ethanediyl-4,1-piperazinediyl))bis (7-chloroquinoline)

InChi Key

ZMBDVIZOGAJHAC-UHFFFAOYSA-N

InChi Code

InChI=1S/C34H42Cl2N8/c35-27-1-3-29-31(25-27)37-7-5-33(29)43-21-17-41(18-22-43)15-13-39-9-11-40(12-10-39)14-16-42-19-23-44(24-20-42)34-6-8-38-32-26-28(36)2-4-30(32)34/h1-8,25-26H,9-24H2

SMILES Code

ClC1=CC=C2C(N3CCN(CCN4CCN(CCN5CCN(C6=CC=NC7=CC(Cl)=CC=C67)CC5)CC4)CC3)=CC=NC2=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 633.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: [Anti-malarial agent, tripiperaquine]. Zhonghua Yi Xue Za Zhi. 1974;(8):488-92, 142. Chinese. PubMed PMID: 4212545. 2: Onori E, Majori G. Recent acquisitions on chemotherapy and chemoprophylaxis of malaria. Ann Ist Super Sanita. 1989;25(4):659-73. Review. PubMed PMID: 2698608. 3: Yang R, Yang C, Hao Y. [Study on the reversing effect of tripiperaquine on human multidrug resistant leukemic cell line K562/A02]. Zhonghua Zhong Liu Za Zhi. 1995 Sep;17(5):340-2. Chinese. PubMed PMID: 8697970. 4: Preliminary studies on tripiperaquine (M 1020). Chin Med J (Engl). 1975 Nov;1(6):419-24. PubMed PMID: 812675. 5: Xu DY, Chen X, Yin XS, Ning XM. [Studies on synthetic antimalarials. VI. The synthesis and antimalarial activity of some new piperaquine analogues , tripiperaquines]. Yao Xue Xue Bao. 1983 Jan;18(1):20-4. Chinese. PubMed PMID: 6344554.