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MedKoo Cat#: 565326 | Name: BZ194

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BZ194 is a potent antagonist of NAADP-induced Ca2+ release in T-lymphocytes for autoimmune disease.

Chemical Structure

BZ194
BZ194
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565326

Name: BZ194

CAS#: NONE

Chemical Formula: C16H25BrN2O3

Exact Mass: 372.1049

Molecular Weight: 373.29

Elemental Analysis: C, 51.48; H, 6.75; Br, 21.41; N, 7.50; O, 12.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BZ-194; BZ 194; BZ194
IUPAC/Chemical Name
3-carboxy-1-(2-(octylamino)-2-oxoethyl)pyridin-1-ium bromide
InChi Key
LCFXDNPKEWPCGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N2O3.BrH/c1-2-3-4-5-6-7-10-17-15(19)13-18-11-8-9-14(12-18)16(20)21;/h8-9,11-12H,2-7,10,13H2,1H3,(H-,17,19,20,21);1H
SMILES Code
O=C(NCCCCCCCC)C[N+]1=CC=CC(C(O)=O)=C1.[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 373.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL. Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease. Sci Rep. 2018 Nov 13;8(1):16775. doi: 10.1038/s41598-018-34917-3. PubMed PMID: 30425261; PubMed Central PMCID: PMC6233153. 2: Nebel M, Zhang B, Odoardi F, Flügel A, Potter BV, Guse AH. Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation. Messenger (Los Angel). 2015 Jun;4(1):104-111. PubMed PMID: 27747143; PubMed Central PMCID: PMC5065091. 3: Connolly MJ, Prieto-Lloret J, Becker S, Ward JP, Aaronson PI. Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release. J Physiol. 2013 Sep 15;591(18):4473-98. doi: 10.1113/jphysiol.2013.253682. Epub 2013 Jun 17. PubMed PMID: 23774281; PubMed Central PMCID: PMC3784194. 4: Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock AC, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M, Geisler A, Herich L, Schlegel S, Carrier L, Eschenhagen T, Potter BV, Ehmke H, Guse AH. Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation. J Biol Chem. 2013 May 31;288(22):16017-30. doi: 10.1074/jbc.M112.441246. Epub 2013 Apr 5. PubMed PMID: 23564460; PubMed Central PMCID: PMC3668757. 5: Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A. Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain. 2010 Jul;133(Pt 7):1930-43. doi: 10.1093/brain/awq135. Epub 2010 Jun 2. PubMed PMID: 20519328; PubMed Central PMCID: PMC2892943. 6: Dammermann W, Zhang B, Nebel M, Cordiglieri C, Odoardi F, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel A, Guse AH, Potter BV. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83. doi: 10.1073/pnas.0809997106. Epub 2009 Jun 16. PubMed PMID: 19541638; PubMed Central PMCID: PMC2697110.