Hycanthone is an antischistosomal agent and active metabolite of lucanthone, known for its activity against Schistosoma mansoni. It acts primarily by inhibiting RNA synthesis through intercalation into DNA and interfering with topoisomerase II activity. In vitro, Hycanthone exhibits cytotoxic effects in various cancer cell lines, with IC₅₀ values typically in the low micromolar range (e.g., ~3–10 µM in HeLa and L1210 cells). In vivo studies have shown significant reduction in worm burden in infected mice treated with 60 mg/kg/day orally for 3 days
MedKoo Cat#: 573620
Name: Hycanthone mesylate
CAS#: 23255-93-8 (mesylate)
Chemical Formula: C21H28N2O5S2
Exact Mass: 452.1440
Molecular Weight: 452.58
Elemental Analysis: C, 55.73; H, 6.24; N, 6.19; O, 17.68; S, 14.17
The following data is based on the product molecular weight 452.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
