Synonym
AI3-61947; AI361947; Berberal; Berberin sulfate; Berberine sulfate; Berberine sulphate; Berberine hemisulfate
IUPAC/Chemical Name
Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, sulfate (2:1) (9CI)
InChi Key
OJVABJMSSDUECT-UHFFFAOYSA-L
InChi Code
1S/2C20H18NO4.H2O4S/c2*1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;1-5(2,3)4/h2*3-4,7-10H,5-6,11H2,1-2H3;(H2,1,2,3,4)/q2*+1;/p-2
SMILES Code
COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.COC6=C(OC)C7=C[N+]8=C(C(C(CC8)=C9)=CC%10=C9OCO%10)C=C7C=C6.O=S([O-])([O-])=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
768.79
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gholampour F, Keikha S. Berberine protects the liver and kidney against functional disorders and histological damages induced by ferrous sulfate. Iran J Basic Med Sci. 2018 May;21(5):476-482. doi: 10.22038/IJBMS.2018.25199.6241. PubMed PMID: 29922427; PubMed Central PMCID: PMC6000217.
2: Zhang LC, Wang Y, Tong LC, Sun S, Liu WY, Zhang S, Wang RM, Wang ZB, Li L. Berberine alleviates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress. Exp Ther Med. 2017 Jun;13(6):3374-3382. doi: 10.3892/etm.2017.4402. Epub 2017 Apr 28. PubMed PMID: 28587416; PubMed Central PMCID: PMC5450762.
3: Li YH, Xiao HT, Hu DD, Fatima S, Lin CY, Mu HX, Lee NP, Bian ZX. Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses. Pharmacol Res. 2016 Aug;110:227-239. doi: 10.1016/j.phrs.2016.02.010. Epub 2016 Mar 9. PubMed PMID: 26969793.
4: Zhou L, Song F, Liu Q, Yang M, Zhao J, Tan R, Xu J, Zhang G, Quinn JM, Tickner J, Xu J. Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-κB and NFAT Pathways. Int J Mol Sci. 2015 Nov 13;16(11):27087-96. doi: 10.3390/ijms161125998. PubMed PMID: 26580592; PubMed Central PMCID: PMC4661856.
