MedKoo Cat#: 573615 | Name: Camptothecin sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Camptothecin sodium selectively inhibits the nuclear enzyme DNA Topoisomerase, Type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Chemical Structure

Camptothecin sodium
Camptothecin sodium
CAS#25387-67-1 (sodium)

Theoretical Analysis

MedKoo Cat#: 573615

Name: Camptothecin sodium

CAS#: 25387-67-1 (sodium)

Chemical Formula: C20H17N2NaO5

Exact Mass: 388.1035

Molecular Weight: 388.35

Elemental Analysis: C, 61.86; H, 4.41; N, 7.21; Na, 5.92; O, 20.60

Price and Availability

Size Price Availability Quantity
25mg USD 285.00 2 weeks
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Synonym
20(S)-Camptothecin sodium salt, AI3-62931, Camptothecine sodium, Camptothecin, sodium salt, Camptothecin sodium, NSC-100880, Sodium camptothecin
IUPAC/Chemical Name
Indolizino(1,2-b)quinoline-7-acetic acid, alpha-ethyl-9,11-dihydro-alpha-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt, (S)- (9CI)
InChi Key
HVGXXVCXEMRSLD-BDQAORGHSA-N
InChi Code
1S/C20H15N2O4.Na/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24;/h3-8H,2,9-10H2,1H3;/q-1;+1/t20-;/m0./s1
SMILES Code
CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccccc5c4)[O-].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 388.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ibrahim S, Gao D, Sinko PJ. Selective cytotoxicity and combined effects of camptothecin or paclitaxel with sodium-R-alpha lipoate on A549 human non-small cell lung cancer cells. Nutr Cancer. 2014;66(3):492-9. doi: 10.1080/01635581.2013.749290. Epub 2013 Sep 24. PubMed PMID: 24063429; PubMed Central PMCID: PMC3964140. 2: Lauricella M, Calvaruso G, Giuliano M, Carabillò M, Emanuele S, Vento R, Tesoriere G. Synergistic cytotoxic interactions between sodium butyrate, MG132 and camptothecin in human retinoblastoma Y79 cells. Tumour Biol. 2000 Nov-Dec;21(6):337-48. PubMed PMID: 11006574.