MYCMI-6, also known as NSC354961, is a selective, high affinity inhibitor of MYC-MAX interaction. MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity ligation, microscale thermophoresis and surface plasmon resonance (SPR) assays. Further, MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a KD of 1.6 ± 0.5 μM as demonstrated by SPR.
MedKoo Cat#: 408005
Name: MYCMI-6
CAS#: 681282-09-7 (free base)
Chemical Formula: C20H19N7O
Exact Mass: 373.1651
Molecular Weight: 373.42
Elemental Analysis: C, 64.33; H, 5.13; N, 26.26; O, 4.28
The following data is based on the product molecular weight 373.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
