MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 573587 | Name: Ciladopa hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ciladopa hydrochloride is a dopaminergic agonist that may be useful in the treatment of Parkinson's disease.

Chemical Structure

Ciladopa hydrochloride
Ciladopa hydrochloride
CAS#83529-09-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 573587

Name: Ciladopa hydrochloride

CAS#: 83529-09-3 (HCl)

Chemical Formula: C21H27ClN2O4

Exact Mass: 406.1659

Molecular Weight: 406.91

Elemental Analysis: C, 61.99; H, 6.69; Cl, 8.71; N, 6.88; O, 15.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
83529-09-3 (HCl) 80109-27-9 (free base)
Synonym
AY-27,110; Ciladopa HCl, Ciladopa hydrochloride, Tremerase
IUPAC/Chemical Name
2,4,6-Cycloheptatrien-1-one, 2-(4-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-1-piperazinyl)-, monohydrochloride, (S)-
InChi Key
UIOUCVPFPQUSAS-FSRHSHDFSA-N
InChi Code
1S/C21H26N2O4.ClH/c1-26-20-9-8-16(14-21(20)27-2)19(25)15-22-10-12-23(13-11-22)17-6-4-3-5-7-18(17)24;/h3-9,14,19,25H,10-13,15H2,1-2H3;1H/t19-;/m1./s1
SMILES Code
COc1ccc(cc1OC)[C@@H](CN2CCN(CC2)c3cccccc3=O)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 406.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Koller WC, Herbster G. D1 and D2 dopamine receptor mechanisms in dopaminergic behaviors. Clin Neuropharmacol. 1988 Jun;11(3):221-31. PubMed PMID: 3261198. 2: Weiner WJ, Berger JR. Effect of ciladopa on Parkinson's disease: a preliminary report. Adv Neurol. 1987;45:583-6. PubMed PMID: 3548268. 3: Koller WC, Fields JZ, Gordon JH, Perlow MJ. Evaluation of ciladopa hydrochloride as a potential anti-Parkinson drug. Neuropharmacology. 1986 Sep;25(9):973-9. PubMed PMID: 3774130. 4: Voith K. The comparative long-term effects of ciladopa (AY-27,110), a chemically novel dopaminergic agonist, in 6-OHDA-lesioned and intact rats. Psychopharmacology (Berl). 1985;85(4):405-9. PubMed PMID: 3927334.